Transbulbar B-mode sonography in multiple sclerosis without optic neuritis; clinical relevance

•OND, ONSD and OND/ONSD ratio is lower among MS patients compared to healthy controls.•Both optic nerve's axons and their myelin sheaths become diminished in size in MS patients•TBS is applicable for MS diagnosis and progression assay by detection of optic nerve damages. Trans bulbar B-mode son...

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Published in:Brain research 2020-05, Vol.1734, p.146723-146723, Article 146723
Main Authors: Raeesmohammadi, Leila, Esmaeili, Sara, Abbasi, Mohammad Hossein, Mehrpour, Masoud, Mirzaasgari, Zahra, Baradaran, Hamid Reza, Deilami, Parvaneh, Motamed, Mohammad Reza
Format: Article
Language:English
Subjects:
Multiple sclerosis
Optic nerve
Trans bulbar B-mode sonography
Visual evoked potential
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Summary:•OND, ONSD and OND/ONSD ratio is lower among MS patients compared to healthy controls.•Both optic nerve's axons and their myelin sheaths become diminished in size in MS patients•TBS is applicable for MS diagnosis and progression assay by detection of optic nerve damages. Trans bulbar B-mode sonography (TBS) is a recently proposed method but there is little known about its diagnostic accuracy in patients with multiple sclerosis without acute optic neuritis. Therefore we assessed the correlation between OND, ONSD and OND/ONSD ratio with clinical/para clinical parameters. In a comparative study, we intended to examine possible differences in optic nerve diameter (OND) and optic nerve sheath diameter (ONSD) between 60 patients with multiple sclerosis (MS) and 60 individuals as matched healthy controls. The OND, ONSD and OND/ONSD ratio in both eyes showed significantly lower amounts in patients compared to healthy controls (p 
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2020.146723