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Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized Controlled Study
Previous studies indicated a positive effect of vitamin K2 (VK2) supplementation on bone turnover biomarkers and bone mineral density (BMD), but the doses varied, and few studies have focused on the difference between VK2 supplementation alone and in combination with calcium and vitamin D 3 . The ai...
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| Published in: | Calcified tissue international 2020-05, Vol.106 (5), p.476-485 |
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| creator | Zhang, Yingfeng Liu, Zhipeng Duan, Lili Ji, Yeyu Yang, Sen Zhang, Yuan Li, Hongyin Wang, Yu Wang, Peng Chen, Jiepeng Li, Ying |
| description | Previous studies indicated a positive effect of vitamin K2 (VK2) supplementation on bone turnover biomarkers and bone mineral density (BMD), but the doses varied, and few studies have focused on the difference between VK2 supplementation alone and in combination with calcium and vitamin D
3
. The aim of this study was to explore a low and effective dose of VK2 for improving BMD, and to examine whether the co-supplementation of VK2, calcium and vitamin D
3
would bring greater effects. In this trial, a total of 311 community-dwelling men and postmenopausal women aged 50 and 75 years were randomly assigned to four groups, receiving placebo, 50 µg/day, 90 µg/day or co-supplementation with calcium (500 mg/day) and vitamin D
3
(10 µg/day) for 1 year. At the endpoint, the bone loss of femoral neck was significantly lower in postmenopausal women in the two 90 µg groups (treatment × time,
p
= 0.006) compared with placebo, but no effects in men. Serum biomarkers cOC/ucOC ratio increased in the intervention groups (treatment × time,
p
|
| doi_str_mv | 10.1007/s00223-020-00669-4 |
| format | article |
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3
. The aim of this study was to explore a low and effective dose of VK2 for improving BMD, and to examine whether the co-supplementation of VK2, calcium and vitamin D
3
would bring greater effects. In this trial, a total of 311 community-dwelling men and postmenopausal women aged 50 and 75 years were randomly assigned to four groups, receiving placebo, 50 µg/day, 90 µg/day or co-supplementation with calcium (500 mg/day) and vitamin D
3
(10 µg/day) for 1 year. At the endpoint, the bone loss of femoral neck was significantly lower in postmenopausal women in the two 90 µg groups (treatment × time,
p
= 0.006) compared with placebo, but no effects in men. Serum biomarkers cOC/ucOC ratio increased in the intervention groups (treatment × time,
p
< 0.001). VK2 supplementation in dose of 90 µg/day performed a significant effect on reducing bone loss in postmenopausal women, but in combination with calcium and vitamin D
3
brought no additional effects.
Trial registration
This trial was registered at
http://www.chictr.org.cn
as chiCTR1800019240.</description><identifier>ISSN: 0171-967X</identifier><identifier>EISSN: 1432-0827</identifier><identifier>DOI: 10.1007/s00223-020-00669-4</identifier><identifier>PMID: 32060566</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Biomarkers ; Biomedical and Life Sciences ; Bone density ; Bone loss ; Bone mineral density ; Bone turnover ; Calcium ; Cell Biology ; chiCTR ; chiCTR1800019240 ; Endocrinology ; Geriatrics ; Hormone replacement therapy ; Life Sciences ; Menaquinones ; Original Research ; Orthopedics ; Osteoporosis ; Post-menopause ; Supplements ; Vitamin D3</subject><ispartof>Calcified tissue international, 2020-05, Vol.106 (5), p.476-485</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-1b4c8f28159930dcdba1d9cd28e44bf0b9120e764eee250681ca438825bce1213</citedby><cites>FETCH-LOGICAL-c375t-1b4c8f28159930dcdba1d9cd28e44bf0b9120e764eee250681ca438825bce1213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32060566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Yingfeng</creatorcontrib><creatorcontrib>Liu, Zhipeng</creatorcontrib><creatorcontrib>Duan, Lili</creatorcontrib><creatorcontrib>Ji, Yeyu</creatorcontrib><creatorcontrib>Yang, Sen</creatorcontrib><creatorcontrib>Zhang, Yuan</creatorcontrib><creatorcontrib>Li, Hongyin</creatorcontrib><creatorcontrib>Wang, Yu</creatorcontrib><creatorcontrib>Wang, Peng</creatorcontrib><creatorcontrib>Chen, Jiepeng</creatorcontrib><creatorcontrib>Li, Ying</creatorcontrib><title>Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized Controlled Study</title><title>Calcified tissue international</title><addtitle>Calcif Tissue Int</addtitle><addtitle>Calcif Tissue Int</addtitle><description>Previous studies indicated a positive effect of vitamin K2 (VK2) supplementation on bone turnover biomarkers and bone mineral density (BMD), but the doses varied, and few studies have focused on the difference between VK2 supplementation alone and in combination with calcium and vitamin D
3
. The aim of this study was to explore a low and effective dose of VK2 for improving BMD, and to examine whether the co-supplementation of VK2, calcium and vitamin D
3
would bring greater effects. In this trial, a total of 311 community-dwelling men and postmenopausal women aged 50 and 75 years were randomly assigned to four groups, receiving placebo, 50 µg/day, 90 µg/day or co-supplementation with calcium (500 mg/day) and vitamin D
3
(10 µg/day) for 1 year. At the endpoint, the bone loss of femoral neck was significantly lower in postmenopausal women in the two 90 µg groups (treatment × time,
p
= 0.006) compared with placebo, but no effects in men. Serum biomarkers cOC/ucOC ratio increased in the intervention groups (treatment × time,
p
< 0.001). VK2 supplementation in dose of 90 µg/day performed a significant effect on reducing bone loss in postmenopausal women, but in combination with calcium and vitamin D
3
brought no additional effects.
Trial registration
This trial was registered at
http://www.chictr.org.cn
as chiCTR1800019240.</description><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Bone density</subject><subject>Bone loss</subject><subject>Bone mineral density</subject><subject>Bone turnover</subject><subject>Calcium</subject><subject>Cell Biology</subject><subject>chiCTR</subject><subject>chiCTR1800019240</subject><subject>Endocrinology</subject><subject>Geriatrics</subject><subject>Hormone replacement therapy</subject><subject>Life Sciences</subject><subject>Menaquinones</subject><subject>Original Research</subject><subject>Orthopedics</subject><subject>Osteoporosis</subject><subject>Post-menopause</subject><subject>Supplements</subject><subject>Vitamin D3</subject><issn>0171-967X</issn><issn>1432-0827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kcuKFDEUhoMoTjv6Ai4k4MZN9ORSqSp3bU97wR4ER8VdkaqcGjOkkjapQtoX8LXN2KOCC8OBhJPv_Al8hDzk8JQD1M8ygBCSgQAGoHXL1C2y4koKBo2ob5MV8JqzVtefT8i9nK8AuNJa3yUnUoCGSusV-bEdRxxmGke6i9_YWcxIP7nZTC7Qt4JeLPu9xwnDbGYXAy31Igak5y5gMp6eYchuPtBCnztrPbL1JVpqgqVbbzH5A918KWzG53RN35d-nNz3QmximFP0vhwv5sUe7pM7o_EZH9zsp-Tjy-2HzWu2e_fqzWa9Y4Osq5nxXg3NKBpeta0EO9jecNsOVjSoVD9C33IBWGuFiKIC3fDBKNk0ouoH5ILLU_LkmLtP8euCee4mlwf03gSMS-6ErKpWalWLgj7-B72KSwrld4VqWl6WuKbEkRpSzDnh2O2Tm0w6dBy6a03dUVNXNHW_NHWqDD26iV76Ce2fkd9eCiCPQC5X4RLT37f_E_sTi9acfg</recordid><startdate>20200501</startdate><enddate>20200501</enddate><creator>Zhang, Yingfeng</creator><creator>Liu, Zhipeng</creator><creator>Duan, Lili</creator><creator>Ji, Yeyu</creator><creator>Yang, Sen</creator><creator>Zhang, Yuan</creator><creator>Li, Hongyin</creator><creator>Wang, Yu</creator><creator>Wang, Peng</creator><creator>Chen, Jiepeng</creator><creator>Li, Ying</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200501</creationdate><title>Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized Controlled Study</title><author>Zhang, Yingfeng ; 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3
. The aim of this study was to explore a low and effective dose of VK2 for improving BMD, and to examine whether the co-supplementation of VK2, calcium and vitamin D
3
would bring greater effects. In this trial, a total of 311 community-dwelling men and postmenopausal women aged 50 and 75 years were randomly assigned to four groups, receiving placebo, 50 µg/day, 90 µg/day or co-supplementation with calcium (500 mg/day) and vitamin D
3
(10 µg/day) for 1 year. At the endpoint, the bone loss of femoral neck was significantly lower in postmenopausal women in the two 90 µg groups (treatment × time,
p
= 0.006) compared with placebo, but no effects in men. Serum biomarkers cOC/ucOC ratio increased in the intervention groups (treatment × time,
p
< 0.001). VK2 supplementation in dose of 90 µg/day performed a significant effect on reducing bone loss in postmenopausal women, but in combination with calcium and vitamin D
3
brought no additional effects.
Trial registration
This trial was registered at
http://www.chictr.org.cn
as chiCTR1800019240.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32060566</pmid><doi>10.1007/s00223-020-00669-4</doi><tpages>10</tpages></addata></record> |
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| language | eng |
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| source | Springer Nature |
| subjects | Biochemistry Biomarkers Biomedical and Life Sciences Bone density Bone loss Bone mineral density Bone turnover Calcium Cell Biology chiCTR chiCTR1800019240 Endocrinology Geriatrics Hormone replacement therapy Life Sciences Menaquinones Original Research Orthopedics Osteoporosis Post-menopause Supplements Vitamin D3 |
| title | Effect of Low-Dose Vitamin K2 Supplementation on Bone Mineral Density in Middle-Aged and Elderly Chinese: A Randomized Controlled Study |
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