Potential biomarkers for early detection of diabetic kidney disease

•An inverse correlation was observed between eGFR and galectin-3 and the GDF-15 plasma level.•Levels of biomarkers increases as the kidney function worsens.•ROC curve confirms the potential of galectin-3 and GDF-15 as a biomarker of DKD. To assess the potential of galectin-3 and growth differentiati...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2020-03, Vol.161, p.108082-108082, Article 108082
Main Authors: Hussain, Salman, Habib, Anwar, Hussain, Md Sarfaraj, Najmi, Abul Kalam
Format: Article
Language:English
Subjects:
Aged
Biomarker
Biomarkers - metabolism
Chronic kidney disease
Cross-Sectional Studies
Diabetic kidney disease
Diabetic Nephropathies - diagnosis
Early Diagnosis
Female
Galectin 3 - metabolism
Galectin-3, GDF-15
Glomerular Filtration Rate - immunology
Growth Differentiation Factor 15 - metabolism
Humans
Kidney - pathology
Male
Middle Aged
T2DM
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Summary:•An inverse correlation was observed between eGFR and galectin-3 and the GDF-15 plasma level.•Levels of biomarkers increases as the kidney function worsens.•ROC curve confirms the potential of galectin-3 and GDF-15 as a biomarker of DKD. To assess the potential of galectin-3 and growth differentiation factor-15 (GDF-15) biomarkers for the early detection of diabetic kidney disease (DKD). This was a cross-sectional study conducted over a period of 1.2 years. Patients were stratified based on estimated glomerular filtration rate (eGFR) and albuminuria level. The receiver operating characteristic (ROC) curve was plotted to assess the diagnostic potential of biomarkers. A total of 90 patients included in this study. Patients were grouped as normoalbuminuria (30 patients), microalbuminuria (30 patients), and macroalbuminuria (30 patients). Galectin-3 and GDF-15 levels were significantly elevated in T2DM patients with macroalbuminuria (p =
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2020.108082