A molecular recognition-activatable DNA nanofirecracker enables signal-enhanced imaging in living cells

We propose an aptamer-tethered DNA nanofirecracker probe that realizes molecular recognition-activatable disassembly of the DNA nanostructure for imaging of target molecules in living cells. The design principle offers a new paradigm to develop nucleic acid nanocircuits for live-cell study and manip...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-03, Vol.56 (21), p.3131-3134
Main Authors: Xing, Xiaojing, Li, Jin, Qiu, Liping, Tan, Weihong
Format: Article
Language:English
Subjects:
Aptamers, Nucleotide - chemistry
Cells (biology)
Deoxyribonucleic acid
DNA
DNA - chemistry
Fluorescent Dyes - chemistry
Humans
MCF-7 Cells
Nanostructures - chemistry
Optical Imaging
RNA, Messenger - analysis
Target recognition
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We propose an aptamer-tethered DNA nanofirecracker probe that realizes molecular recognition-activatable disassembly of the DNA nanostructure for imaging of target molecules in living cells. The design principle offers a new paradigm to develop nucleic acid nanocircuits for live-cell study and manipulation. An aptamer-tethered DNA nanofirecracker probe that realizes molecular recognition-activatable disassembly of the DNA nanostructure for signal-enhanced bioimaging in living cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc09682e