Efficacy and safety of delivery of topical medication on to the frontal sinus at different head positions after frontal sinusotomy

• Published in: European archives of oto-rhino-laryngology 2020-05, Vol.277 (5), p.1361-1368
• Main Authors: Wu, Yu-Xiao, Wang, Min, Li, Hui, Xing, Zhi-Min, Shi, Mu-Han, Huang, Shi-En, Liu, Yan, Geng, Cong-Li
• Format: Article
• Language: English
• Subjects: Chronic Disease; Endoscopy; Frontal Sinus - surgery; Head and Neck Surgery; Humans; Medicine; Medicine & Public Health; Neurosurgery; Otorhinolaryngology; Pharmaceutical Preparations; Prospective Studies; Rhinology; Sinusitis - drug therapy; Sinusitis - surgery
• ISSN: 0937-4477; 1434-4726
• DOI: 10.1007/s00405-020-05851-w

Purpose Effective topical medications delivery to the frontal sinus is crucial to recovery from frontal sinusotomy. However, finding a way to deliver local medications to the frontal sinus is still a major challenge. The objective of this study was to evaluate the influence of various head positions on postoperative frontal sinus drug deposition. The safety and efficacy were also evaluated in postoperative chronic rhinosinusitis (CRS) patients. Methods Full house surgery was performed on six fresh frozen cadaver heads. The fluorescein solution was dropped into the nasal sinuses in three different head positions, and the fluorescein deposition was evaluated. A prospective cohort study was performed to validate the results in 20 postoperative CRS patients. The cortisol level, symptom VAS and the frontal recess endoscopy scores were evaluated pre- and postoperatively. Results The frontal recess delivery of fluorescein was better in the Mygind and vertex-to-floor positions than in the head back position. The cortisol level of patients dropped markedly after taking oral methylprednisolone, but returned to baseline when replaced with budesonide drops. The pre- and postoperative symptom VAS scores did not differ significantly between the two groups. Endoscopic scores of the vertex-to-floor group were significantly better than those of the Mygind group. Conclusion Both the Mygind and the vertex-to-floor head positions were optimal for delivery of topical medications to the frontal recess. When applying the steroid drops, both positions were found to be safe and associated with effective relief of symptoms. The vertex-to-floor position can better improve the endoscopic scores of frontal recess and frontal sinus.