Evaluation of increased arterial stiffness in pediatric patients with cystic fibrosis by augmentation index and pulse wave velocity analysis

With the increase in life expectancy, cardiovascular complications of cystic fibrosis (CF) have come to the forefront. Increased arterial stiffness is a marker of increased cardiovascular risk. The aim of this study was to compare both pulse wave velocity (PWV) and augmentation index (Aix) measureme...

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Bibliographic Details
Published in:Pediatric pulmonology 2020-05, Vol.55 (5), p.1147-1153
Main Authors: Kartal Öztürk, Gökçen, Conkar, Seçil, Eşki, Aykut, Gülen, Figen, Keskinoğlu, Ahmet, Demir, Esen
Format: Article
Language:English
Subjects:
arterial stiffness
augmentation index
Cystic fibrosis
Health risk assessment
pulse wave velocity analysis
Risk factors
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Summary:With the increase in life expectancy, cardiovascular complications of cystic fibrosis (CF) have come to the forefront. Increased arterial stiffness is a marker of increased cardiovascular risk. The aim of this study was to compare both pulse wave velocity (PWV) and augmentation index (Aix) measurements in children with CF and to compare them with healthy controls. We hypothesized that children with CF had increased arterial stiffness, although traditional risk factors for CVD were not observed. Forty‐four patients and age and sex‐matched 30 healthy controls were included in the study. Hemodynamic measurements were compared in both groups, together with traditional risk factors. Peripheral blood pressure parameters of CF and control groups were similar (P > .05). Bodyweight and BMI were significantly lower in the CF group (P 
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.24688