Response to Letter to the editor by Signe Sørup re: The risk of non-specific hospitalised infections following MMR vaccination given with and without inactivated vaccines in the second year of life. Comparative self-controlled case-series study in England

According to the hypothesis that any beneficial effects of a live vaccine are annulled by its co-administration with an inactivated vaccine, this change should not matter as any positive effects of OPV would be negated by Diphtheria-Tetanus-Pertussis vaccine (DTP) and the two additional co-administe...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2020-02, Vol.38 (9), p.2116-2116
Main Authors: Andrews, Nick, Stowe, Julia, Walker, Jemma, Thomas, Sara, Miller, Liz
Format: Article
Language:English
Subjects:
Age
Diphtheria
Immunization
Infections
Pertussis
Poliomyelitis
Tetanus
Vaccines
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:According to the hypothesis that any beneficial effects of a live vaccine are annulled by its co-administration with an inactivated vaccine, this change should not matter as any positive effects of OPV would be negated by Diphtheria-Tetanus-Pertussis vaccine (DTP) and the two additional co-administered inactivated vaccines. According to proponents of non-specific effects hypotheses this shows either a detrimental effect of DTP with no beneficial effect of OPV on survival, or a beneficial effect of OPV that is negated by co-administration with DTP. [...]our main aim is to compare the relative incidence estimates between the two periods. [...]as we note in the paper, this possible source of bias should have a minimal effect on our results.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2020.01.012