Microbiome of the first stool after birth and infantile colic

Background Recent studies have shown a diverse microbiome in the first stool after birth. The clinical significance of the microbiome of the first stool is not known. Infantile colic has earlier been associated with the composition of the intestinal microbiome. Methods We set out to test whether the...

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Bibliographic Details
Published in:Pediatric research 2020-11, Vol.88 (5), p.776-783
Main Authors: Korpela, Katja, Renko, Marjo, Paalanne, Niko, Vänni, Petri, Salo, Jarmo, Tejesvi, Mysore, Koivusaari, Pirjo, Pokka, Tytti, Kaukola, Tuula, Pirttilä, Anna Maria, Tapiainen, Terhi
Format: Article
Language:English
Subjects:
Clinical Research Article
Infantile colic
Medicine
Medicine & Public Health
Pediatric Surgery
Pediatrics
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Summary:Background Recent studies have shown a diverse microbiome in the first stool after birth. The clinical significance of the microbiome of the first stool is not known. Infantile colic has earlier been associated with the composition of the intestinal microbiome. Methods We set out to test whether the microbiome of the first stool is associated with subsequent infantile colic in a prospective, population-based cohort study of 212 consecutive newborn infants. We used next-generation sequencing of the bacterial 16S rRNA gene. Results The newborns who later developed infantile colic ( n  = 19) had a lower relative abundance of the genus Lactobacillus and the phylum Firmicutes in the first stool than those who remained healthy ( n  = 139). By using all microbiome data, random forest algorithm classified newborn with subsequent colic and those who remained healthy with area under the curve of 0.66 (SD 0.03) as compared to that of shuffled samples ( P value
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-020-0804-y