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Anticancer palladium-doped magnesia nanoparticles: synthesis, characterization, and in vitro study
To prepare, physicochemically characterize and determine the anticancer effects of palladium-doped magnesia (Pd/MgO) nanoparticles. Pd/MgO nanoparticles were prepared by the co-precipitation method from the aqueous solution of Mg(NO ) .6H O using K CO and the impregnation of MgO into palladium acety...
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| Published in: | Nanomedicine (London, England) England), 2020-03, Vol.15 (6), p.547-561 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 561 |
| container_issue | 6 |
| container_start_page | 547 |
| container_title | Nanomedicine (London, England) |
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| creator | Al-Fahdawi, Mohamed Qasim Rasedee, Abdullah Al-Doghachi, Faris Aj Rosli, Rozita Taufiq-Yap, Yun Hun Al-Qubaisi, Mothanna Sadiq |
| description | To prepare, physicochemically characterize and determine the anticancer effects of palladium-doped magnesia (Pd/MgO) nanoparticles.
Pd/MgO nanoparticles were prepared by the co-precipitation method from the aqueous solution of Mg(NO
)
.6H
O using K
CO
and the impregnation of MgO into palladium acetylacetonate.
Pd/MgO nanoparticles were between 47 and 70 nm in size, cuboid in shape, and tended to form aggregates. Nanoparticles were more antiproliferative toward cancer than the normal cells. In cancer cells, Pd/MgO nanoparticles induced apoptosis by increasing caspase activities and stimulating cytochrome C release. The anticancer effects of Pd/MgO nanoparticles were accentuated by the upregulation of Bax and p53 and downregulation of Bcl-2 protein expressions.
Pd/MgO nanoparticles have potential to be developed as an anticancer compound. |
| doi_str_mv | 10.2217/nnm-2019-0178 |
| format | article |
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Pd/MgO nanoparticles were prepared by the co-precipitation method from the aqueous solution of Mg(NO
)
.6H
O using K
CO
and the impregnation of MgO into palladium acetylacetonate.
Pd/MgO nanoparticles were between 47 and 70 nm in size, cuboid in shape, and tended to form aggregates. Nanoparticles were more antiproliferative toward cancer than the normal cells. In cancer cells, Pd/MgO nanoparticles induced apoptosis by increasing caspase activities and stimulating cytochrome C release. The anticancer effects of Pd/MgO nanoparticles were accentuated by the upregulation of Bax and p53 and downregulation of Bcl-2 protein expressions.
Pd/MgO nanoparticles have potential to be developed as an anticancer compound.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm-2019-0178</identifier><identifier>PMID: 32063101</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Apoptosis ; Cancer therapies ; Cell culture ; Cell growth ; Cytochrome ; Deoxyribonucleic acid ; DNA ; Morphology ; Nanoparticles ; Nitrogen ; Proteins ; Scanning electron microscopy ; Spectrum analysis ; Transmission electron microscopy ; Variance analysis</subject><ispartof>Nanomedicine (London, England), 2020-03, Vol.15 (6), p.547-561</ispartof><rights>Copyright Future Medicine Ltd Mar 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c321t-20e18da49dc9933a1154dc6bd2cac9c9f338e8a3e153196c5a63ae98ba46b4d53</citedby><cites>FETCH-LOGICAL-c321t-20e18da49dc9933a1154dc6bd2cac9c9f338e8a3e153196c5a63ae98ba46b4d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32063101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al-Fahdawi, Mohamed Qasim</creatorcontrib><creatorcontrib>Rasedee, Abdullah</creatorcontrib><creatorcontrib>Al-Doghachi, Faris Aj</creatorcontrib><creatorcontrib>Rosli, Rozita</creatorcontrib><creatorcontrib>Taufiq-Yap, Yun Hun</creatorcontrib><creatorcontrib>Al-Qubaisi, Mothanna Sadiq</creatorcontrib><title>Anticancer palladium-doped magnesia nanoparticles: synthesis, characterization, and in vitro study</title><title>Nanomedicine (London, England)</title><addtitle>Nanomedicine (Lond)</addtitle><description>To prepare, physicochemically characterize and determine the anticancer effects of palladium-doped magnesia (Pd/MgO) nanoparticles.
Pd/MgO nanoparticles were prepared by the co-precipitation method from the aqueous solution of Mg(NO
)
.6H
O using K
CO
and the impregnation of MgO into palladium acetylacetonate.
Pd/MgO nanoparticles were between 47 and 70 nm in size, cuboid in shape, and tended to form aggregates. Nanoparticles were more antiproliferative toward cancer than the normal cells. In cancer cells, Pd/MgO nanoparticles induced apoptosis by increasing caspase activities and stimulating cytochrome C release. The anticancer effects of Pd/MgO nanoparticles were accentuated by the upregulation of Bax and p53 and downregulation of Bcl-2 protein expressions.
Pd/MgO nanoparticles have potential to be developed as an anticancer compound.</description><subject>Apoptosis</subject><subject>Cancer therapies</subject><subject>Cell culture</subject><subject>Cell growth</subject><subject>Cytochrome</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Morphology</subject><subject>Nanoparticles</subject><subject>Nitrogen</subject><subject>Proteins</subject><subject>Scanning electron microscopy</subject><subject>Spectrum analysis</subject><subject>Transmission electron microscopy</subject><subject>Variance analysis</subject><issn>1743-5889</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNpdkE1LxDAQhoMofqwevUrAiwermaRNE28ifsGCFz2HaZLVyDatSSusv96uXwdPMzAPL_M-hBwCO-Mc6vMY24Iz0AWDWm2QXahLVUgtxebXLopKKb1D9nJ-ZaxSHNg22RGcSQEMdklzGYdgMVqfaI_LJbowtoXreu9oi8_R54A0Yux6TBO49PmC5lUcXqZDPqX2BRPawafwgUPo4inF6GiI9D0MqaN5GN1qn2wtcJn9wc-ckaeb68eru2L-cHt_dTkvrOAwTCU8KIeldlZrIRCgKp2VjeMWrbZ6IYTyCoWHSoCWtkIp0GvVYCmb0lViRk6-c_vUvY0-D6YN2fqpU_TdmA0XlZQgea0m9Pgf-tqNKU7fGV6qGupKqHVg8U3Z1OWc_ML0KbSYVgaYWcs3k3yzlm_W8if-6Cd1bFrv_uhf2-ITyoyA1Q</recordid><startdate>202003</startdate><enddate>202003</enddate><creator>Al-Fahdawi, Mohamed Qasim</creator><creator>Rasedee, Abdullah</creator><creator>Al-Doghachi, Faris Aj</creator><creator>Rosli, Rozita</creator><creator>Taufiq-Yap, Yun Hun</creator><creator>Al-Qubaisi, Mothanna Sadiq</creator><general>Future Medicine Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>EHMNL</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>202003</creationdate><title>Anticancer palladium-doped magnesia nanoparticles: synthesis, characterization, and in vitro study</title><author>Al-Fahdawi, Mohamed Qasim ; Rasedee, Abdullah ; Al-Doghachi, Faris Aj ; Rosli, Rozita ; Taufiq-Yap, Yun Hun ; Al-Qubaisi, Mothanna Sadiq</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c321t-20e18da49dc9933a1154dc6bd2cac9c9f338e8a3e153196c5a63ae98ba46b4d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Apoptosis</topic><topic>Cancer therapies</topic><topic>Cell culture</topic><topic>Cell growth</topic><topic>Cytochrome</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Morphology</topic><topic>Nanoparticles</topic><topic>Nitrogen</topic><topic>Proteins</topic><topic>Scanning electron microscopy</topic><topic>Spectrum analysis</topic><topic>Transmission electron microscopy</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al-Fahdawi, Mohamed Qasim</creatorcontrib><creatorcontrib>Rasedee, Abdullah</creatorcontrib><creatorcontrib>Al-Doghachi, Faris Aj</creatorcontrib><creatorcontrib>Rosli, Rozita</creatorcontrib><creatorcontrib>Taufiq-Yap, Yun Hun</creatorcontrib><creatorcontrib>Al-Qubaisi, Mothanna Sadiq</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>UK & Ireland Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Nanomedicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al-Fahdawi, Mohamed Qasim</au><au>Rasedee, Abdullah</au><au>Al-Doghachi, Faris Aj</au><au>Rosli, Rozita</au><au>Taufiq-Yap, Yun Hun</au><au>Al-Qubaisi, Mothanna Sadiq</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anticancer palladium-doped magnesia nanoparticles: synthesis, characterization, and in vitro study</atitle><jtitle>Nanomedicine (London, England)</jtitle><addtitle>Nanomedicine (Lond)</addtitle><date>2020-03</date><risdate>2020</risdate><volume>15</volume><issue>6</issue><spage>547</spage><epage>561</epage><pages>547-561</pages><issn>1743-5889</issn><eissn>1748-6963</eissn><abstract>To prepare, physicochemically characterize and determine the anticancer effects of palladium-doped magnesia (Pd/MgO) nanoparticles.
Pd/MgO nanoparticles were prepared by the co-precipitation method from the aqueous solution of Mg(NO
)
.6H
O using K
CO
and the impregnation of MgO into palladium acetylacetonate.
Pd/MgO nanoparticles were between 47 and 70 nm in size, cuboid in shape, and tended to form aggregates. Nanoparticles were more antiproliferative toward cancer than the normal cells. In cancer cells, Pd/MgO nanoparticles induced apoptosis by increasing caspase activities and stimulating cytochrome C release. The anticancer effects of Pd/MgO nanoparticles were accentuated by the upregulation of Bax and p53 and downregulation of Bcl-2 protein expressions.
Pd/MgO nanoparticles have potential to be developed as an anticancer compound.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>32063101</pmid><doi>10.2217/nnm-2019-0178</doi><tpages>15</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1743-5889 |
| ispartof | Nanomedicine (London, England), 2020-03, Vol.15 (6), p.547-561 |
| issn | 1743-5889 1748-6963 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2356616278 |
| source | PubMed (Medline) |
| subjects | Apoptosis Cancer therapies Cell culture Cell growth Cytochrome Deoxyribonucleic acid DNA Morphology Nanoparticles Nitrogen Proteins Scanning electron microscopy Spectrum analysis Transmission electron microscopy Variance analysis |
| title | Anticancer palladium-doped magnesia nanoparticles: synthesis, characterization, and in vitro study |
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