Polysaccharide Based Hemostatic Strategy for Ultrarapid Hemostasis

• Published in: Macromolecular bioscience 2020-04, Vol.20 (4), p.e1900370-n/a
• Main Authors: Chen, Yeyi, Wu, Lei, Li, Pengpeng, Hao, Xiao, Yang, Xiao, Xi, Guanghui, Liu, Wen, Feng, Yakai, He, Hongchao, Shi, Changcan
• Format: Article
• Language: English
• Subjects: Alginates - chemistry; Alginates - pharmacology; Animals; Bandages; Biocompatibility; Biocompatible Materials - chemical synthesis; Biocompatible Materials - pharmacology; Biodegradability; Biodegradation; Bleeding; Cellulose - analogs & derivatives; Cellulose - pharmacology; Chemical composition; Chitosan - analogs & derivatives; Chitosan - pharmacology; Complications; Dextrans - chemistry; Dextrans - pharmacology; Gauze; Hemorrhage; Hemorrhage - prevention & control; Hemostasis; Hemostasis - drug effects; Hemostasis - physiology; hemostatic strategy; Hemostatics; Hemostatics - chemical synthesis; Hemostatics - pharmacology; Humans; Hyaluronic Acid - analogs & derivatives; Hyaluronic Acid - pharmacology; Hydrogels; Hydrogels - chemistry; Hydrogels - pharmacology; Medical materials; Microspheres; Military applications; Morbidity; Platelet Aggregation - drug effects; Polysaccharides; Saccharides; Sponges; Starch - analogs & derivatives; Starch - pharmacology; Time Factors
• ISSN: 1616-5187; 1616-5195
• DOI: 10.1002/mabi.201900370

Bleeding complications usually cause significant morbidity and mortality in civilian and military populations. In clinical application, hemostatic sponges, gauzes, hydrogel, and bandages are widely used as the traditional effective hemostatic products for hemorrhage. However, the traditional hemostatic devices or agents cannot meet the requirement for treatment of massive bleeding. Therefore, the excellent hemostatic performance of hemostatic products are of great significance for saving lives. Natural polysaccharides, as the main chemical component, have been widely used in the preparation of hemostasis due to their perfect biocompatibility and biodegradability. Polysaccharide based hemostatic products are available in variety of forms, such as, hydrogel, sponges, gauze and microspheres. The purpose of the present review is to report the research progress on polysaccharide hemostatic products and technology. In the present review, hemostatic strategies of traditional materials are discussed. The properties of common hemostatic products in a variety of forms, such as, hydrogels, sponges, and gauze, are investigated. Polysaccharides have great advantages and application prospects in ultrarapid hemostasis. Different polysaccharide based hemostatic materials, such as chitosan, cellulose, dextran, alginate, hyaluronic acid, and starch are summarized.