Protective effects of naringin against drugs and chemical toxins induced hepatotoxicity: A review

The liver is a vital metabolic organ for drug and xenobiotic metabolism which is influenced by chemical and natural toxins. Liver injury is associated with systemic oxidative stress, which leads to cellular necrosis, fibrosis, tissue lipid peroxidation, and depletion in glutathione levels. Consideri...

Full description

Saved in:
Bibliographic Details
Published in:Phytotherapy research 2020-08, Vol.34 (8), p.1734-1744
Main Authors: Shirani, Kobra, Yousefsani, Bahare Sadat, Shirani, Maryam, Karimi, Gholamreza
Format: Article
Language:English
Subjects:
Antioxidants
Citrus fruits
Depletion
Drug metabolism
Drugs
Fibrosis
Flavonoids
Glutathione
Hepatotoxicity
Inflammation
Lipid peroxidation
Lipids
Liver
Medicinal plants
naringin
Necrosis
Oxidative stress
Peroxidation
Toxicants
toxicity
Toxins
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The liver is a vital metabolic organ for drug and xenobiotic metabolism which is influenced by chemical and natural toxins. Liver injury is associated with systemic oxidative stress, which leads to cellular necrosis, fibrosis, tissue lipid peroxidation, and depletion in glutathione levels. Considering the lack of reliable hepato‐protective drugs in modern medicine, plant‐derived phytoconstituents seem to be a noteworthy option. Naringin is an abundant flavonoid found in citrus fruits with various pharmacological benefits such as antioxidant, anti‐inflammatory, and antiapoptotic, activities. In this review, we summarize available data from recent studies about the hepatoprotective effects of naringin against chemical toxicants and discuss the possible mechanisms of actions. Hepatoprotective effects of naringin against chemical and natural toxins.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.6641