Renin-angiotensin system in mammalian kidney development

Mutations in the genes of the renin-angiotensin system result in congenital anomalies of the kidney and urinary tract (CAKUT), the main cause of end-stage renal disease in children. The molecular mechanisms that cause CAKUT are unclear in most cases. To improve the care of children with CAKUT, it is...

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Bibliographic Details
Published in:Pediatric nephrology (Berlin, West) West), 2021-03, Vol.36 (3), p.479-489
Main Author: Yosypiv, Ihor V.
Format: Article
Language:English
Subjects:
Angiotensin
Animals
Bladder
Children
Congenital defects
Embryonic development
End-stage renal disease
Endocrine system
Genetic aspects
Health aspects
Humans
Kidney
Kidney Diseases
Kidneys
Mammals
Medicine
Medicine & Public Health
Molecular modelling
Mutation
Nephrology
Pediatrics
Peptides
Physiological aspects
Protein expression
Proteins
Renin
Renin-Angiotensin System
Review
Smooth muscle
Urinary tract
Urogenital Abnormalities
Urogenital system
Urology
Vesico-Ureteral Reflux
What’s new in Renal Development
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Summary:Mutations in the genes of the renin-angiotensin system result in congenital anomalies of the kidney and urinary tract (CAKUT), the main cause of end-stage renal disease in children. The molecular mechanisms that cause CAKUT are unclear in most cases. To improve the care of children with CAKUT, it is critical to determine the underlying mechanisms of CAKUT. In this review, we discuss recent advances that have helped to better understand how disruption of the renin-angiotensin system during kidney development contributes to CAKUT.
ISSN:0931-041X
1432-198X
DOI:10.1007/s00467-020-04496-5