Association between mean arterial pressure and risk of type 2 diabetes mellitus: The Rural Chinese Cohort Study

• Published in: Primary care diabetes 2020-10, Vol.14 (5), p.448-454
• Main Authors: Guo, Chunmei, Qin, Pei, Li, Quanman, Zhang, Dongdong, Tian, Gang, Liu, Dechen, Liu, Leilei, Cheng, Cheng, Chen, Xu, Qie, Ranran, Han, Minghui, Huang, Shengbing, Zhou, Qionggui, Liu, Feiyan, Wu, Xiaoyan, Zhao, Yang, Ren, Yongcheng, Liu, Yu, Sun, Xizhuo, Li, Honghui, Wang, Bingyuan, Zhang, Ming, Lu, Jie, Hu, Dongsheng
• Format: Article
• Language: English
• Subjects: Cohort study; Mean arterial pressure; Type 2 diabetes mellitus
• ISSN: 1751-9918; 1878-0210
• DOI: 10.1016/j.pcd.2020.01.007

•The study explored the association between mean arterial pressure and T2DM.•A large sample size in rural Chinese people.•Restricted cubic spline models were used to evaluate the dose–response association.•Subgroup and sensitivity analyses were also performed. Limited evidence is available on the association of mean arterial pressure and risk of type 2 diabetes mellitus (T2DM) among Chinese people. We aimed to investigate the association between MAP and risk of T2DM in rural Chinese adults. We performed a cohort study of 12,284 eligible participants (4668 men and 7616 women) without T2DM at baseline. Cox proportional-hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of MAP with risk of T2DM. Restricted cubic spline models were used to evaluate the dose–response association between MAP and risk of T2DM. During a median of 6.01 years follow-up (73,403.52 person-years), T2DM developed in 847 participants (318 men and 529 women). In the multivariable-adjusted models, risk of T2DM was significantly higher for women with the third (90−100mmHg) and fourth MAP categories (≥100mmHg) than the first category (