Higher Circulating Adiponectin Concentrations Predict Incident Cancer in Type 2 Diabetes – The Adiponectin Paradox

Abstract Introduction Despite the beneficial cardiometabolic effects of adiponectin demonstrated in preclinical studies, paradoxically higher circulating adiponectin concentrations have been found in epidemiological studies to be associated with incident cardiovascular events, renal outcomes, and mo...

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Published in:The journal of clinical endocrinology and metabolism 2020-04, Vol.105 (4), p.e1387-e1396
Main Authors: Lee, Chi Ho, Lui, David T W, Cheung, Chloe Y Y, Fong, Carol H Y, Yuen, Michele M A, Chow, Wing Sun, Woo, Yu Cho, Xu, Aimin, Lam, Karen S L
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - blood
Aged
Biomarkers - blood
Cancer
Confidence intervals
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - physiopathology
Epidemiology
Female
Follow-Up Studies
Hong Kong - epidemiology
Humans
Kidney diseases
Male
Middle Aged
Neoplasms - epidemiology
Prognosis
Prospective Studies
Registries - statistics & numerical data
Risk Factors
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Summary:Abstract Introduction Despite the beneficial cardiometabolic effects of adiponectin demonstrated in preclinical studies, paradoxically higher circulating adiponectin concentrations have been found in epidemiological studies to be associated with incident cardiovascular events, renal outcomes, and mortality in patients with diabetes. On the other hand, diabetes is also associated with an increased risk of cancer. Here, we investigated prospectively the association between circulating adiponectin concentrations and incident cancer using a cohort of exclusively individuals with type 2 diabetes. Materials and Methods Baseline serum adiponectin concentrations were measured in 5658 participants recruited from the Hong Kong West Diabetes Registry. The associations of circulating adiponectin concentrations with incident cancer and cancer-related deaths were evaluated using multivariable Cox regression analysis, with hazard ratio (HR) for adiponectin referring to the respective risk per doubling of serum adiponectin concentration. Results Over a median-follow up of 6.5 years, 7.53% and 3% of participants developed cancer and had cancer-related deaths, respectively. Serum adiponectin concentrations were significantly higher in those who had incident cancer (9.8 μg/mL vs 9.1 μg/mL, P 
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgaa075