Positive correlation of serum fibroblast growth factor 23 with peripheral arterial stiffness in kidney transplantation patients

• Published in: Clinica chimica acta 2020-06, Vol.505, p.9-14
• Main Authors: Liu, Yao-Chang, Tsai, Jen-Pi, Wang, Li-Hsuan, Lee, Ming-Che, Hsu, Bang-Gee
• Format: Article
• Language: English
• Subjects: Animals; Arterial stiffness; Biomarkers; Fibroblast growth factor 23; Fibroblast Growth Factors - analysis; Fibroblast Growth Factors - metabolism; Humans; Kidney Function Tests; Kidney Transplantation; Renal Insufficiency, Chronic - metabolism; Renal Insufficiency, Chronic - physiopathology; Renal transplantation; α-Klotho
• ISSN: 0009-8981; 1873-3492
• DOI: 10.1016/j.cca.2020.02.014

•FGF-23 level is positively correlated with peripheral AS in RT recipients.•α-Klotho level is not associated with peripheral AS in RT recipients.•FGF-23 level is positively correlated with serum log-Cre level in RT recipients.•FGF-23 level is positively correlated with serum phosphorus level in RT recipients.•FGF-23 level is negatively correlated with serum calcium level in RT recipients. Fibroblast growth factor 23 (FGF-23) has a role in arterial stiffness (AS) apart from regulating mineral metabolism. We investigated the association between FGF-23 concentration and peripheral AS in renal transplantation (RT) recipients. The fasting blood samples of RT recipients (n = 66) were collected and analyzed. A total of 29 (43.9%) RT recipients were classified under the peripheral AS group. The RT recipients in this group had a higher prevalence of diabetes (P