Efficiency of whole-body 18F-FDG PET CT in detecting the cause of rising serum AFP level in post-therapeutic follow-up for HCC patients

Purpose The goal of this study was to assess the value of whole-body 18 F-FDG PET/CT in detecting the cause of rising serum alpha-fetoprotein (AFP) level after the treatment of hepatocellular carcinoma (HCC). Materials and methods 18 F-FDG PET/CT studies were performed for 100 patients (76 men and 2...

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Bibliographic Details
Published in:Japanese journal of radiology 2020-05, Vol.38 (5), p.472-479
Main Authors: Ali, Susan Adil, Amin, Darine Helmy, Abdelkhalek, Yasser Ibrahim
Format: Article
Language:English
Subjects:
Computed tomography
Fluorine isotopes
Hepatocellular carcinoma
Imaging
Lesions
Liver cancer
Medicine
Medicine & Public Health
Metastases
Nuclear Medicine
Original Article
Patients
Positron emission
Positron emission tomography
Radiology
Radiotherapy
Sensitivity
Tomography
α-Fetoprotein
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Summary:Purpose The goal of this study was to assess the value of whole-body 18 F-FDG PET/CT in detecting the cause of rising serum alpha-fetoprotein (AFP) level after the treatment of hepatocellular carcinoma (HCC). Materials and methods 18 F-FDG PET/CT studies were performed for 100 patients (76 men and 24 women), ranged in age from 40 to 76 years who had underwent either surgical resection or interventional therapy for HCC, but were subsequently noted to have rising AFP serum level on routine follow-up examinations. The 18 F-FDG PET/CT results were correlated with histological findings or radiological and clinical follow-up. Results According to patient-based analysis, 18 F-FDG PET/CT demonstrated 74 true-positives, four false-negatives, 16 true-negative, and 6 false-positive results, with sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 95%, 72.7%, 92.5%, 80%, and 90%, respectively. According to Lesion-based analysis, 18 F-FDG PET/CT demonstrated 202 true-positive lesions, 8 false-negatives, and 16 true-negative and 6 false-positive results, with sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 98%, 72.7%, 97%, 80%, and 95.6%, respectively. Conclusion 18 F-FDG PET/CT is a valuable imaging tool investigating patients who have a rising serum AFP level after HCC treatment. It accurately detects residual or recurrent tumor as well as extrahepatic metastasis.
ISSN:1867-1071
1867-108X
DOI:10.1007/s11604-020-00930-8