The therapeutic effect of B‐type natriuretic peptides in acute decompensated heart failure

B‐type natriuretic peptide (BNP) exhibits roles in natriuresis and diuresis, making it an ideal drug that may aid in diuresing a fluid‐overloaded patient with poor or worsening renal function. Several randomized clinical trials have tested the hypothesis that infusions of pharmacological doses of BN...

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Published in:Clinical and experimental pharmacology & physiology 2020-07, Vol.47 (7), p.1120-1133
Main Authors: Caprnda, Martin, Zulli, Anthony, Shiwani, Haaris A., Kubatka, Peter, Filipova, Slavomira, Valentova, Vanda, Gazdikova, Katarina, Mozos, Ioana, Berukstis, Andrius, Laucevicius, Aleksandras, Rihacek, Ivan, Dragasek, Jozef, Prosecky, Robert, Egom, Emmanuel E., Staffa, Robert, Kruzliak, Peter, Krasnik, Vladimir
Format: Article
Language:English
Subjects:
Acute Disease
Animals
B‐type natriuretic peptide
clinical effectiveness
Clinical trials
Congestive heart failure
Diuresis
Heart failure
Heart Failure - blood
Heart Failure - drug therapy
Heart Failure - physiopathology
Humans
Natriuretic Peptide, Brain - blood
Natriuretic Peptide, Brain - therapeutic use
Peptides
pharmacotherapy
Renal function
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Summary:B‐type natriuretic peptide (BNP) exhibits roles in natriuresis and diuresis, making it an ideal drug that may aid in diuresing a fluid‐overloaded patient with poor or worsening renal function. Several randomized clinical trials have tested the hypothesis that infusions of pharmacological doses of BNP to acute heart failure (HF) patients may enhance decongestion and preserve renal function in this clinical setting. Unfortunately, none of these have demonstrated beneficial outcomes. The current challenge for BNP research in acute HF lies in addressing a failure of concept and a reluctance to abandon an ineffective research model. Future success will necessitate a detailed understanding of the mechanism of action of BNP, as well as better integration of basic and clinical science.
ISSN:0305-1870
1440-1681
1440-1681
DOI:10.1111/1440-1681.13290