Antidiabetic activity of Musa x paradisiaca extracts in streptozotocin-induced diabetic rats and chemical characterization by HPLC-DAD-MS

• Published in: Journal of ethnopharmacology 2020-05, Vol.254, p.112666-112666, Article 112666
• Main Authors: Vilhena, R.O., Figueiredo, I.D., Baviera, A.M., Silva, D.B., Marson, B.M., Oliveira, J.A., Peccinini, R.G., Borges, I.K., Pontarolo, R.
• Format: Article
• Language: English
• Subjects: Animals; Anthocyanins; Banana; Blood Glucose - drug effects; Chromatography, High Pressure Liquid; Diabetes mellitus; Diabetes Mellitus, Experimental - drug therapy; Flowers - chemistry; Glucose Tolerance Test; HPLC-DAD-MS; Hydroxycinnamic acid derivatives; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacology; Male; Mass Spectrometry; Musa - chemistry; Phytochemicals - analysis; Plant Extracts - analysis; Plant Extracts - chemistry; Plant Extracts - pharmacology; Rats
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/j.jep.2020.112666

The Musa x paradisiaca L. inflorescence, known as banana blossom or banana heart, is used in traditional medicine for the treatment of diabetes mellitus. Aim of the study: The aim of the study was to investigate the antidiabetic activity of aqueous extracts and fractions prepared from the bracts and flowers of Musa x paradisiaca in streptozotocin (STZ)-induced diabetic rats and to chemically characterize the extracts. Standard aqueous extracts of the flowers, bracts, and their fractions were prepared and their chemical composition was determined tentatively by high-performance liquid chromatography coupled to diode-array detection and mass spectrometry (HPLC-DAD-MS). Changes in fasting glycemia and oral glucose tolerance were evaluated in STZ-induced diabetic rats (n = 8) treated with aqueous extracts of Musa x paradisiaca (200 mg/kg) for 20 days. Chemical analyses detected 21 compounds and 17 metabolites were identified, among which were glycosylated and acetylated phenylpropanoids of p-coumaric acid and caffeic acid, as well as a glycosylated flavonol and anthocyanins. Following 15 days of treatment, the bract aqueous extracts and the methanolic fraction of the flower had significant effects on the glycemic profile after glucose load in diabetic rats as compared with the untreated diabetic group. The results of the present study show the antidiabetic potential of extracts of the flowers and bracts of M. x paradisiaca. [Display omitted]