Role of Apelin/APJ axis in cancer development and progression

Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The apelin receptor, called angiotensin-like-receptor 1 (APJ), is also expressed in the brain, spleen, placenta, heart, li...

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Bibliographic Details
Published in:Advances in medical sciences 2020-03, Vol.65 (1), p.202-213
Main Authors: Masoumi, Javad, Jafarzadeh, Abdollah, Khorramdelazad, Hossein, Abbasloui, Morteza, Abdolalizadeh, Jalal, Jamali, Najmeh
Format: Article
Language:English
Subjects:
Animals
Apelin
Apelin - metabolism
Apelin Receptors - metabolism
Cancer
Disease Progression
Humans
Neoplasms - metabolism
Neoplasms - pathology
Neovascularization, Pathologic - metabolism
Neovascularization, Pathologic - pathology
Therapeutic potentials
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Summary:Apelin is an endogenous peptide, which is expressed in a vast board of organs such as the brain, placenta, heart, lungs, kidneys, pancreas, testis, prostate and adipose tissues. The apelin receptor, called angiotensin-like-receptor 1 (APJ), is also expressed in the brain, spleen, placenta, heart, liver, intestine, prostate, thymus, testis, ovary, lungs, kidneys, stomach, and adipose tissue. The apelin/APJ axis is involved in a number of physiological and pathological processes. The apelin expression is increased in various kinds of cancer and the apelin/APJ axis plays a key role in the development of tumors through enhancing angiogenesis, metastasis, cell proliferation and also through the development of cancer stem cells and drug resistance. The apelin also stops the apoptosis of cancer cells. The apelin/APJ axis was considered in this review as an attractive therapeutic target for cancer treatment.
ISSN:1896-1126
1898-4002
DOI:10.1016/j.advms.2020.02.002