Determinants of neonatal hypoglycemia after antenatal administration of corticosteroids (ACS) for lung maturation: Data from two referral centers and review of the literature

A correlation between ACS and neonatal hypoglycemia has been recently demonstrated. The aim of the study was to evaluate the determinants of neonatal hypoglycemia in women exposed to ACS for respiratory distress syndrome prevention. Retrospective, multicenter, cohort study conducted in two Tertiary...

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Published in:Early human development 2020-04, Vol.143, p.104984-104984, Article 104984
Main Authors: di Pasquo, Elvira, Saccone, Gabriele, Angeli, Laura, Dall'Asta, Andrea, Borghi, Elena, Fieni, Stefania, Berghella, Vincenzo, Magnani, Cinzia, Frusca, Tiziana, Ghi, Tullio
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - administration & dosage
Adrenal Cortex Hormones - adverse effects
Adrenal Cortex Hormones - therapeutic use
Adult
Birth Weight
Corticosteroids
Female
Humans
Hypoglycemia
Hypoglycemia - epidemiology
Hypoglycemia - etiology
Infant, Newborn
Infant, Newborn, Diseases - epidemiology
Infant, Newborn, Diseases - etiology
Lung - embryology
Male
Neonate
Pregnancy
Premature Birth - prevention & control
Prenatal Exposure Delayed Effects - epidemiology
Prenatal Exposure Delayed Effects - etiology
Respiratory distress
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Summary:A correlation between ACS and neonatal hypoglycemia has been recently demonstrated. The aim of the study was to evaluate the determinants of neonatal hypoglycemia in women exposed to ACS for respiratory distress syndrome prevention. Retrospective, multicenter, cohort study conducted in two Tertiary University Units. All fetuses delivered from 2016 to 2017 after ACS (two doses i.m. of Betamethasone 12 mg 24 h apart) were considered eligible for the study purpose. The primary outcome was the incidence of hypoglycemia, defined as a glycemic value ≤45 mg/dl within the first 48 h of neonatal life. The effect on neonatal glycaemia due to timing (interval from exposure to delivery) and type (single completed, single partial or repeated course) of ACS administration was also assessed. Overall, 99 neonates met the inclusion criteria. Hypoglycemia occurred in 38/99 (38.4%) of the included newborns. Compared to normoglycemic neonates, those with hypoglycemia had lower gestational age at delivery (33.06 ± 3.37 vs. 35.94 ± 3.17 g; p 
ISSN:0378-3782
1872-6232
DOI:10.1016/j.earlhumdev.2020.104984