Premature ageing following allogeneic hematopoietic stem cell transplantation

Survivors of hematopoietic cell transplantation (HCT) have been shown to exhibit both clinical and biological features of accelerated ageing. Most studies used frailty measures, comorbidities for clinical assessment and several biological assessment of premature ageing. However, these tests are less...

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Published in:Bone marrow transplantation (Basingstoke) 2020-07, Vol.55 (7), p.1438-1446
Main Authors: Uziel, Orit, Lahav, Meir, Shargian, Liat, Beery, Einat, Pasvolsky, Oren, Rozovski, Uri, Raanani, Pia, Yeshurun, Moshe
Format: Article
Language:English
Subjects:
13
13/106
631/67/1990
631/80
Age determination
Aging
Blood cells
Bone marrow
Cell Biology
Chronology
Deoxyribonucleic acid
DNA
DNA methylation
Epithelial cells
Epithelium
Gene expression
Hematology
Hematopoietic stem cells
INK4a protein
Interleukin 6
Internal Medicine
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Methylation
p16 Protein
Public Health
Serum levels
Stem cell transplantation
Stem Cells
Survival
Telomeres
Transplantation
Transplants & implants
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cited_by cdi_FETCH-LOGICAL-c541t-a141ea454b802c3a2eff3d2499bf7643a2db34374d4688e425acc771cee1a8233
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container_title Bone marrow transplantation (Basingstoke)
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creator Uziel, Orit
Lahav, Meir
Shargian, Liat
Beery, Einat
Pasvolsky, Oren
Rozovski, Uri
Raanani, Pia
Yeshurun, Moshe
description Survivors of hematopoietic cell transplantation (HCT) have been shown to exhibit both clinical and biological features of accelerated ageing. Most studies used frailty measures, comorbidities for clinical assessment and several biological assessment of premature ageing. However, these tests are less suitable for age determination of individual patients. Recently, DNA methylation has emerged as a novel test to measure cellular age. In the present study, we assessed ageing in a cohort of 26 survivors of allogeneic HCT by frailty tests comprising the handgrip and 6 min walk tests and by biological tests including DNA methylation, telomere length and expression of p16INK 4A and serum levels of IL-6. DNA methylation was evaluated both in blood and buccal epithelial cells. Physiological reserve was markedly reduced in transplant survivors, reflected by 6 min walk test. Increased IL-6 serum levels and p16 ink4A correlated with accelerated ageing. Overall, the measured age of donor blood cells was significantly higher than these blood cells residing in their respective donors, as reflected by DNA methylation and by buccal epithelium methylation status. These clinical and biological observations suggest that allogeneic HCT is associated with accelerated ageing.
doi_str_mv 10.1038/s41409-020-0839-z
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ispartof Bone marrow transplantation (Basingstoke), 2020-07, Vol.55 (7), p.1438-1446
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source Nexis UK; Springer Nature
subjects 13
13/106
631/67/1990
631/80
Age determination
Aging
Blood cells
Bone marrow
Cell Biology
Chronology
Deoxyribonucleic acid
DNA
DNA methylation
Epithelial cells
Epithelium
Gene expression
Hematology
Hematopoietic stem cells
INK4a protein
Interleukin 6
Internal Medicine
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Methylation
p16 Protein
Public Health
Serum levels
Stem cell transplantation
Stem Cells
Survival
Telomeres
Transplantation
Transplants & implants
title Premature ageing following allogeneic hematopoietic stem cell transplantation
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