Prognostic value of the metabolic bulk volume in patients with diffuse large B-cell lymphoma on baseline 18F-FDG PET-CT

We retrospectively investigated the prognostic value of the metabolic bulk volume (MBV), defined as the metabolic volume of the largest lesion, in 106 patients with diffuse large B-cell lymphoma who underwent baseline 18 FDG PET-CT. Semi-automatically segmented (41% SUV max ) total metabolic tumor v...

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Bibliographic Details
Published in:Leukemia & lymphoma 2020-07, Vol.61 (7), p.1584-1591
Main Authors: Delaby, Gauthier, Hubaut, Marc-Antoine, Morschhauser, Franck, Besson, Alix, Huglo, Damien, Herbaux, Charles, Baillet, Clio
Format: Article
Language:English
Subjects:
diffuse large B-cell lymphoma
Life Sciences
metabolic bulk volume
PET-CT
total metabolic tumor volume
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Summary:We retrospectively investigated the prognostic value of the metabolic bulk volume (MBV), defined as the metabolic volume of the largest lesion, in 106 patients with diffuse large B-cell lymphoma who underwent baseline 18 FDG PET-CT. Semi-automatically segmented (41% SUV max ) total metabolic tumor volume (TMTV) and MBV underwent receiver operating characteristic analysis, identifying optimal thresholds of 147 cm 3 for the TMTV and 41.5 cm 3 for the MBV. A low TMTV and a low MBV were significantly associated with longer progression-free survival (PFS) and overall survival (OS). According to Cox multivariate analysis, the TMTV and MBV were independent predictors, respectively, for PFS (HR = 3.501), and OS (HR = 7.242). The TMTV and MBV classification were discordant in 18.9% of patients with a 5-year PFS rate of 100% for patients with low MBV/high TMTV and 74% for high MBV/low TMTV. The baseline MBV can be an efficient tool for the risk stratification of aggressive lymphoma.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428194.2020.1728750