Volumetric Histogram Analysis of Apparent Diffusion Coefficient as a Biomarker to Predict Survival of Esophageal Cancer Patients

Background The purpose of this study was to investigate whether histogram analysis of an apparent diffusion coefficient (ADC) can serve as a prognostic biomarker for esophageal squamous cell carcinoma (ESCC). Methods This retrospective study enrolled 116 patients with ESCC who received curative surg...

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Bibliographic Details
Published in:Annals of surgical oncology 2020-08, Vol.27 (8), p.3083-3089
Main Authors: Hirata, Atsushi, Hayano, Koichi, Ohira, Gaku, Imanishi, Shunsuke, Hanaoka, Toshiharu, Toyozumi, Takeshi, Murakami, Kentaro, Aoyagi, Tomoyoshi, Shuto, Kiyohiko, Matsubara, Hisahiro
Format: Article
Language:English
Subjects:
Biomarkers
Chemotherapy
Diffusion coefficient
Diffusion Magnetic Resonance Imaging
Esophageal cancer
Esophageal Neoplasms - diagnostic imaging
Esophageal Squamous Cell Carcinoma
Esophagus
Head and Neck Neoplasms
Humans
Lymph nodes
Lymphatic system
Magnetic resonance imaging
Medical prognosis
Medicine
Medicine & Public Health
Multivariate analysis
Oncology
Patients
Retrospective Studies
Squamous cell carcinoma
Surgery
Surgical Oncology
Thoracic Oncology
Tumors
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Summary:Background The purpose of this study was to investigate whether histogram analysis of an apparent diffusion coefficient (ADC) can serve as a prognostic biomarker for esophageal squamous cell carcinoma (ESCC). Methods This retrospective study enrolled 116 patients with ESCC who received curative surgery from 2006 to 2015 (including 70 patients who received neoadjuvant chemotherapy). Diffusion-weighted magnetic resonance imaging (DWI) was performed prior to treatment. The ADC maps were generated by DWIs at b  = 0 and 1000 (s/mm 2 ), and analyzed to obtain ADC histogram-derived parameters (mean ADC, kurtosis, and skewness) of the primary tumor. Associations of these parameters with pathological features were analyzed, and Cox regression and Kaplan–Meier analyses were performed to compare these parameters with recurrence-free survival (RFS) and disease-specific survival (DSS). Results Kurtosis was significantly higher in tumors with lymphatic invasion ( p  = 0.005) with respect to the associations with pathological features. In univariate Cox regression analysis, tumor depth, lymph node status, mean ADC, and kurtosis were significantly correlated with RFS ( p  = 0.047, p  
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-020-08270-7