The polycystic ovary syndrome and gynecological cancer risk

This review updates the knowledge regarding the association between the polycystic ovary syndrome (PCOS) and the risk of gynecological cancer. We performed a literature review of clinical and epidemiological studies concerning PCOS and the risk of breast, endometrial and ovarian cancer after selecti...

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Bibliographic Details
Published in:Gynecological endocrinology 2020-04, Vol.36 (4), p.289-293
Main Authors: Meczekalski, Blazej, Pérez-Roncero, Gonzalo R., López-Baena, María T., Chedraui, Peter, Pérez-López, Faustino R.
Format: Article
Language:English
Subjects:
breast cancer
Breast Neoplasms - epidemiology
Breast Neoplasms - etiology
endometrial cancer
Endometrial Neoplasms - epidemiology
Endometrial Neoplasms - etiology
Female
Genital Neoplasms, Female - epidemiology
Genital Neoplasms, Female - etiology
gynecological cancer
Humans
ovarian cancer
Ovarian Neoplasms - epidemiology
Ovarian Neoplasms - etiology
Polycystic ovary syndrome (PCOS)
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - epidemiology
Risk Factors
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Summary:This review updates the knowledge regarding the association between the polycystic ovary syndrome (PCOS) and the risk of gynecological cancer. We performed a literature review of clinical and epidemiological studies concerning PCOS and the risk of breast, endometrial and ovarian cancer after selecting information by quality of scientific methodology. It was found that evidence does not support a link between PCOS and breast cancer risk. There is an increased risk of endometrial cancer, while data concerning ovarian cancer are contradictory. Regarding PCOS and its association to cervical, fallopian tube, and vulvar cancer, the quality of evidence is heterogeneous. In conclusion, women with PCOS should be screened for endometrial cancer and more research is warranted to determine in this population the true risk of developing other gynecological cancers such as breast and ovarian.
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2020.1730794