Signal regulators of human naïve pluripotency

Pluripotent cells transiently develop during peri-implantation embryogenesis and have the capacity to convert into three embryonic lineages. Two typical states of pluripotency, naïve and primed, can be experimentally induced in vitro. The in vitro naïve state can be stabilized in response to environ...

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Bibliographic Details
Published in:Experimental cell research 2020-04, Vol.389 (2), p.111924-111924, Article 111924
Main Authors: Taei, Adeleh, Rasooli, Paniz, Braun, Thomas, Hassani, Seyedeh-Nafiseh, Baharvand, Hossein
Format: Article
Language:English
Subjects:
Human pluripotent stem cells
Naïve pluripotency
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Summary:Pluripotent cells transiently develop during peri-implantation embryogenesis and have the capacity to convert into three embryonic lineages. Two typical states of pluripotency, naïve and primed, can be experimentally induced in vitro. The in vitro naïve state can be stabilized in response to environmental inductive cues via a unique transcriptional regulatory program. However, interference with various signaling pathways creates a spectrum of alternative pluripotent cells that display different functions and molecular expression patterns. Similarly, human naïve pluripotent cells can be placed into two main levels - intermediate and bona fide. Here, we discuss several culture conditions that have been used to establish naïve-associated gene regulatory networks in human pluripotent cells. We also describe different transcriptional patterns in various culture systems that are associated with these two levels of human naïve pluripotency.
ISSN:0014-4827
1090-2422
DOI:10.1016/j.yexcr.2020.111924