Accuracy of cerebrospinal fluid ferritin for purulent meningitis

ObjectiveTo evaluate the use of cerebrospinal fluid (CSF) ferritin levels in the diagnosis of purulent meningitis (PM).MethodWe studied 81 children between 28 days and 12 years of age who presented with clinical suspicion of meningitis to the emergency department. CSF ferritin levels were measured a...

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Bibliographic Details
Published in:Archives of disease in childhood 2021-03, Vol.106 (3), p.286-289
Main Authors: Garcia, Pedro Celiny Ramos, Barcelos, Andrea Lucia Machado, Tonial, Cristian Tedesco, Fiori, Humberto Holmer, Einloft, Paulo Roberto, Costa, Caroline Abud Drumond, Portela, Janete L, Bruno, Francisco, Branco, Ricardo Garcia
Format: Article
Language:English
Subjects:
Accuracy
Antibiotics
Aseptic meningitis
Attrition (Research Studies)
Bacterial infections
Biomarkers
Biomarkers - analysis
Brazil - epidemiology
Case-Control Studies
Cerebrospinal fluid
Cerebrospinal Fluid - metabolism
Cerebrospinal Fluid - microbiology
Child
Child, Preschool
Children
Childrens health
Cross-Sectional Studies
Cytology
Diagnostic Tests
Emergency medical care
Emergency Service, Hospital
Female
Ferritin
Ferritins - cerebrospinal fluid
Glucose
Guillain-Barre syndrome
Hospitalization
Humans
Infant
Infant, Newborn
Leukocytes
Male
Medical diagnosis
Meningitis
Meningitis, Aseptic - cerebrospinal fluid
Meningitis, Aseptic - diagnosis
Meningitis, Aseptic - microbiology
Meningitis, Bacterial - cerebrospinal fluid
Meningitis, Bacterial - diagnosis
Meningitis, Bacterial - microbiology
Mortality
Neutrophils
Patients
Pediatrics
Proteins
Streptococcus infections
Variables
Viral infections
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Summary:ObjectiveTo evaluate the use of cerebrospinal fluid (CSF) ferritin levels in the diagnosis of purulent meningitis (PM).MethodWe studied 81 children between 28 days and 12 years of age who presented with clinical suspicion of meningitis to the emergency department. CSF ferritin levels were measured and compared between diagnostic groups (PM, aseptic meningitis (AM) and no meningitis).ResultsThe median age was 24 (IQR 8–69) months. There were 32 patients with AM (39%), 23 with PM (28%) and 26 with no meningitis (32%). Median CSF ferritin was 4.2 ng/mL (IQR 3.0–6.5), 52.9 ng/mL (IQR 30.7–103 ng/mL) and 2.4 ng/mL (IQR 2–4), respectively. CSF ferritin was higher in children with PM compared with AM (p
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2019-317960