Cardiovascular autonomic neuropathy: A silent killer with long reach

Cardiovascular autonomic neuropathy (CAN) is a common and deadly complication of diabetes mellitus, which is frequently overlooked in clinical practice due to its characteristic subtle presentation earlier in disease. Yet, timely detection of CAN may help implementation of tailored interventions to...

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Bibliographic Details
Published in:Autonomic neuroscience 2020-05, Vol.225, p.102646-102646, Article 102646
Main Authors: Ang, Lynn, Dillon, Brendan, Mizokami-Stout, Kara, Pop-Busui, Rodica
Format: Article
Language:English
Subjects:
Cardiovascular autonomic dysfunction
Cardiovascular autonomic neuropathy
Cardiovascular disease
Diabetes mellitus
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Summary:Cardiovascular autonomic neuropathy (CAN) is a common and deadly complication of diabetes mellitus, which is frequently overlooked in clinical practice due to its characteristic subtle presentation earlier in disease. Yet, timely detection of CAN may help implementation of tailored interventions to prevent its progression and mitigate the risk of associated complications, including cardiovascular disease (CVD), cardiac arrhythmias, myocardial dysfunction leading to congestive heart failure and all-cause mortality. This review highlights current CAN epidemiology trends, novel mechanisms linking CAN with other diabetes complications and current recommendations for diagnosis and management of the disease in the clinical setting.
ISSN:1566-0702
1872-7484
DOI:10.1016/j.autneu.2020.102646