Frequency and Significance of Coronary Artery Disease and Myocardial Bridging in Patients With Hypertrophic Cardiomyopathy

•CAD was just as common in controls as in hypertrophic cardiomyopathy patients.•Myocardial bridging was twice as prevalent in hypertrophic cardiomyopathy patients.•CT performs well in the evaluation of chest pain in hypertrophic cardiomyopathy. The etiology of chest pain in hypertrophic cardiomyopat...

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Bibliographic Details
Published in:The American journal of cardiology 2020-05, Vol.125 (9), p.1404-1412
Main Authors: van der Velde, Nikki, Huurman, Roy, Yamasaki, Yuzo, Kardys, Isabella, Galema, Tjebbe W, Budde, Ricardo PJ, Zijlstra, Felix, Krestin, Gabriel P, Schinkel, Arend FL, Michels, Michelle, Hirsch, Alexander
Format: Article
Language:English
Subjects:
Age
Angina pectoris
Angiography
Arteriosclerosis
Atherosclerosis
Calcium
Cardiomyopathy
Cardiovascular disease
Chest
Computed tomography
Consortia
Coronary artery
Coronary artery disease
Coronary vessels
Deoxyribonucleic acid
Diabetes
DNA
Dyspnea
Etiology
Heart diseases
Heart failure
Hypertension
Ischemia
Metabolism
Morphology
Mortality
Pain
Patients
Survival analysis
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Summary:•CAD was just as common in controls as in hypertrophic cardiomyopathy patients.•Myocardial bridging was twice as prevalent in hypertrophic cardiomyopathy patients.•CT performs well in the evaluation of chest pain in hypertrophic cardiomyopathy. The etiology of chest pain in hypertrophic cardiomyopathy (HC) is diverse and includes coronary artery disease (CAD) as well as HC-specific causes. Myocardial bridging (MB) has been associated with HC, chest pain, and accelerated atherosclerosis. We compared HC patients with age-, gender- and CAD pre-test probability-matched outpatients presenting with chest pain to investigate differences in the presence of MB and CAD using coronary computed tomography angiography (CCTA). We studied 84 HC patients who underwent CCTA and compared these with 168 matched controls (age 54 ± 11 years, 70% men, pre-test probability 12% [5% to 32%]). MB, calcium score, plaque morphology and presence and extent of CAD were assessed for each patient. Linear mixed models were used to assess differences between cases and controls. MB was more often seen in HC patients (50% vs 25%, p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2020.02.002