Tinospora cordifolia protects from skeletal muscle atrophy by alleviating oxidative stress and inflammation induced by sciatic denervation

Tinospora cordifolia (TC) is widely being used as immunomodulatory and re-juvenile drug and well described in Indian Ayurveda system of medicine. Rejuvenation also means the fine tuning of the skeletal muscles. Skeletal muscle related disorder, i.e. atrophy is major problem which arise due to cachex...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2020-05, Vol.254, p.112720-112720, Article 112720
Main Authors: Sharma, Bhawana, Dutt, Vikas, Kaur, Nirmaljeet, Mittal, Ashwani, Dabur, Rajesh
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - therapeutic use
Antioxidants - therapeutic use
Cell Line
Denervation
Histopathology
Inflammation
Lymphocytes - drug effects
Male
Mice
Muscle Development - drug effects
Muscle, Skeletal - drug effects
Muscular Atrophy - drug therapy
Oxidative stress
Oxidative Stress - drug effects
Plant Extracts - therapeutic use
Plant Leaves
Sciatic denervation
Sciatic Nerve - surgery
Skeletal muscle atrophy
Tinospora
Tinospora cordifolia extract (TCE)
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Summary:Tinospora cordifolia (TC) is widely being used as immunomodulatory and re-juvenile drug and well described in Indian Ayurveda system of medicine. Rejuvenation also means the fine tuning of the skeletal muscles. Skeletal muscle related disorder, i.e. atrophy is major problem which arise due to cachexia, sarcopenia and immobilization. However, despite of the great efforts, there is scarcity of FDA approved drugs in the market to treat skeletal muscle atrophy. The current study was aimed to explore the in-vitro and in-vivo efficacy and mechanism of TC in myogenic differentiation and skeletal muscle atrophy to establish the possibility of its usage to counteract skeletal muscle atrophy. C2C12 cell lines were used to determine myogenic potential and anti-atrophic effects of T. cordifolia water extract (TCE). Its in-vitro efficacy was re-validated in vivo by supplementation of TCE at a dose of 200 mg/kg/p.o. for 30 days in denervated mice model of skeletal muscle atrophy. Effects of TCE administration on levels of oxidative stress, inflammatory markers and proteolysis were determined. TCE supplementation displayed increased lymphocyte proliferation and induced myogenic differentiation of C2C12 myoblasts by significantly increasing myocytes length and thickness, in comparison to control (p 
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2020.112720