Hypolipidemic potential of sterol containing fractions of Jolyna laminarioides: a brown alga

Solvent fractions (n-hexane, cholorofrom, methanol) and fractions containing sterols of Jolyna laminarioides was evaluated in triton-induced and high-fat-diet induced hyperlipidemic rats. Oral administration of J. laminarioides significantly reduced the elevated level of serum total cholesterol, tri...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2020-01, Vol.33 (1), p.169-174
Main Authors: Ruqqia, -, Sohail, Nida, Taj, Darakhshan, Sarwar, Ghulam, Sultana, Viqar, Ara, Jehan, Haque, Syed Ehteshamul
Format: Article
Language:English
Subjects:
Alanine Transaminase - blood
Alkaline Phosphatase - blood
Animals
Aspartate Aminotransferases - blood
Chloroform
Cholesterol - blood
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Diet, High-Fat
Enzymes
Hyperlipidemias - prevention & control
Hypolipidemic Agents - isolation & purification
Hypolipidemic Agents - pharmacology
L-Lactate Dehydrogenase - blood
Low density lipoproteins
Male
Methanol
Phaeophyceae - chemistry
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Leaves - chemistry
Polyethylene Glycols
Rats
Sterols
Sterols - chemistry
Sterols - isolation & purification
Sterols - pharmacology
Triglycerides
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Summary:Solvent fractions (n-hexane, cholorofrom, methanol) and fractions containing sterols of Jolyna laminarioides was evaluated in triton-induced and high-fat-diet induced hyperlipidemic rats. Oral administration of J. laminarioides significantly reduced the elevated level of serum total cholesterol, triglycerides and LDL-c, both in triton induced and high fat diet induced hyperlipidemic rat models with increased serum HDL-c. Chloroform: methanol fraction (2:1) and n-hexane fraction containing sterol showed promising results in reducing LDL-c. The methanol fraction showed hypolipidemic effect by increasing HDL-c (90%). The extracts and fractions of the seaweed also decreased the increased level of cardiac and hepatic marker enzymes beside lowering lipid profile. J. laminarioides exhibited high anti-hyperlipidemic effects both in triton induced and high fat diet induced hyperlipidemic rats.
ISSN:1011-601X
DOI:10.36721/PJPS.2020.33.1.REG.169-174.1