Cerebello-cerebral connectivity in idiopathic generalized epilepsy

• Published in: European radiology 2020-07, Vol.30 (7), p.3924-3933
• Main Authors: Jiang, Sisi, Li, Xiangkui, Li, Zhiliang, Chang, Xuebin, Chen, Yan, Huang, Yang, Zhang, Yanan, Wang, Hongyu, Zuo, Xiaojun, Li, Xin, Yao, Dezhong, Luo, Cheng
• Format: Article
• Language: English
• Subjects: Anisotropy; Cerebellum; Cerebral cortex; Circuits; Convulsions & seizures; Cortex (frontal); Cortex (motor); Cortex (parietal); Dentate nucleus; Diagnostic Radiology; Diffusivity; Epilepsy; Fibers; Imaging; Internal Medicine; Interventional Radiology; Laboratories; Magnetic Resonance; Magnetic resonance imaging; Medicine; Medicine & Public Health; Neuroimaging; Neuroradiology; Occipital lobe; Putamen; Pyramidal tracts; Radiology; Sensory neurons; Somatosensory cortex; Structure-function relationships; Tensors; Ultrasound
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-020-06674-3

Purpose The present study aims to investigate structural and functional connectivity (SC and FC) in cerebello-cerebral circuit in idiopathic generalized epilepsy (IGE). Methods Diffusion tensor imaging and resting-state imaging data were collected from 57 patients with IGE and 66 controls in the present study. First, we performed bidirectional probabilistic fiber tracking between cerebellum and cerebral cortex, consisting of cerebellar efferent and afferent fibers. Then, strength of structural connectivity (SCS), fractional anisotropy (FA), mean diffusivity (MD), and radial diffusivity (RD) were extracted and compared between groups. Finally, cerebellar FC with cerebral cortex was evaluated with seeding at dentate nucleus. Between-group comparisons were performed using t tests with a significant level setting at p