Screening for invasive fungal disease using non‐culture‐based assays among inpatients with advanced HIV disease at a large academic hospital in South Africa

Summary Introduction Despite widespread access to antiretroviral therapy (ART), the burden of advanced HIV disease in South Africa is high. This translates into an increased risk of AIDS‐related opportunistic infections, including invasive mycoses. Methods Using a limited number of non‐culture‐based...

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Bibliographic Details
Published in:Mycoses 2020-05, Vol.63 (5), p.478-487
Main Authors: van Schalkwyk, Erika, Mhlanga, Mabatho, Maphanga, Tsidiso G., Mpembe, Ruth S., Shillubane, Amanda, Iyaloo, Samantha, Tsotetsi, Ernest, Pieton, Kim, Karstaedt, Alan S., Sahid, Faieza, Menezes, Colin N., Tsitsi, Merika, Motau, Ayanda, Wadula, Jeannette, Seetharam, Sharona, van den Berg, Eunice, Sriruttan, Charlotte, Govender, Nelesh P.
Format: Article
Language:English
Subjects:
AIDS
antigen test
Antigens
Antiretroviral therapy
CD4 antigen
Cell culture
cryptococcosis
cryptococcus neoformans
deep fungal infection
Diagnosis
Epidemiology
Fungal diseases
Fungal infections
HIV
HIV infection
Human immunodeficiency virus
Mycosis
Tuberculosis
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Summary:Summary Introduction Despite widespread access to antiretroviral therapy (ART), the burden of advanced HIV disease in South Africa is high. This translates into an increased risk of AIDS‐related opportunistic infections, including invasive mycoses. Methods Using a limited number of non‐culture‐based diagnostic assays, we aimed to determine the prevalence of invasive mycoses and tuberculosis among hospitalised adults with very advanced HIV (CD4 counts 
ISSN:0933-7407
1439-0507
DOI:10.1111/myc.13071