The effects of melatonin on possible damage that will occur on adipocytokines and liver tissue by coadministration of fructose and bisphenol a (BPA)

BPA, one of the environmental endocrine disruptors, and fructose, reason of liver steatosis which is frequently encountered in the daily diet, contribute to the formation of metabolic syndrome (MetS). This study examines the possible effects of concurrent fructose and BPA administration on MetS and...

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Bibliographic Details
Published in:Environmental science and pollution research international 2020-05, Vol.27 (14), p.16231-16245
Main Authors: Akçay, Neslihan Coşkun, Ömeroğlu, Suna, Dizakar, Saadet Özen Akarca, Kavutçu, Mustafa, Türkoğlu, İsmail, Eşmekaya, Meriç Arda, Peker, Tuncay Veysel
Format: Article
Language:English
Subjects:
Annexin V
Antioxidants
Apoptosis
Aquatic Pollution
Atmospheric Protection/Air Quality Control/Air Pollution
Bisphenol A
Collagen
Earth and Environmental Science
Ecotoxicology
Endocrine disruptors
Environment
Environmental Chemistry
Environmental Health
Environmental science
Enzymatic activity
Enzyme activity
Fatty liver
Fructose
Hepatocytes
Lipid peroxidation
Lipids
Liver
Melatonin
Metabolic disorders
Metabolic syndrome
Oxidative stress
Peroxidation
Research Article
Steatosis
Waste Water Technology
Water Management
Water Pollution Control
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Summary:BPA, one of the environmental endocrine disruptors, and fructose, reason of liver steatosis which is frequently encountered in the daily diet, contribute to the formation of metabolic syndrome (MetS). This study examines the possible effects of concurrent fructose and BPA administration on MetS and determines the effects of melatonin on this process. In the seven identified groups, a total of forty-two adult male Sprague Dawley rats were treated by following fructose, BPA, and melatonin amounts, separately and together: group 1 (control), group 2 (10% aqueous fructose), group 3 (25 mg/kg BPA), group 4 (10% fructose + 25 mg/kg BPA), group 5 (10% fructose + 20 mg/kg melatonin), group 6 (25 mg/kg BPA + 20 mg/kg melatonin), and group 7 (10% fructose + 25 mg/kg BPA + 20 mg/kg melatonin). At the end of 60 days, histochemical, immunohistochemical, and biochemical procedures were performed on liver tissue. As a result, it was seen that BPA and fructose + BPA induced morphological alteration and inflammation and increased intracellular lipid quantity and amount of collagen and reticular fibers. The percentage of apoptotic liver cells stained by annexin V-FITC/PI was lower in group 7 compared to the group 4 ( p  
ISSN:0944-1344
1614-7499
DOI:10.1007/s11356-020-08041-7