Splintered tubercular granuloma—A consistent cytological findings in drug defaulters

• Published in: Diagnostic cytopathology 2020-06, Vol.48 (6), p.554-558
• Main Authors: Zaheer, Sufian, Sharma, Rohit, Beg, Farzana, Sherwani, Rana K.
• Format: Article
• Language: English
• Subjects: Biopsy, Fine-Needle; Granuloma - pathology; Granulomas; Humans; India; Lymphatic system; Medication Adherence; Mycobacterium tuberculosis; Tuberculosis; Tuberculosis, Lymph Node - pathology
• ISSN: 8755-1039; 1097-0339
• DOI: 10.1002/dc.24401

Background Tuberculosis remains a major health problem in the less developed nations and is now a major health problem in developed countries, owing to the emergence of human immunodeficiency virus (HIV) infection and (AIDS). However, despite the availability of effective chemotherapy, patient noncompliance with regimens is the most common reason for therapeutic failures. The aim of this study is to describe the cytological features of drug defaulters on lymph node fine‐needle aspiration cytology (FNAC). Objective Due to the common problem of drug defaulters in developing countries like India, we had carried out a study to see the cytological features of drug defaulters on FNAC of the lymph node. Method Three hundred fifty tuberculosis cases, diagnosed based on Mantoux (Mx) test, acid‐fast bacilli and/or culture, were followed up for drug compliance by cervical lymph node FNAC. Result Forty cases were found to be drug defaulters on detailed and meticulous follow‐up. These patients were found to have splintered epithelioid cell granuloma with some viable epithelioid cells enmeshed in fibrous tissue elements. Other findings were degenerating epithelioid cells with or without surrounding eosinophilic infiltration and leaching of the degenerating lymphoid and epithelioid cells. Conclusion Lymph node FNAC can be used to identify tubercular drug defaulters, which may be time consuming and/or expensive by culture or other ancillary means.