Histological and magnified endoscopic evaluation of villous atrophy in gastrointestinal graft-versus-host disease

Aim: To measure histological villous atrophy and to clarify the diagnostic accuracy of endoscopic villous atrophy in gastrointestinal graft-versus-host disease. Methods: Data for patients who underwent upper and/or lower endoscopic examinations after hematopoietic stem cell transplantation were retr...

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Bibliographic Details
Published in:Annals of hematology 2020-05, Vol.99 (5), p.1121-1128
Main Authors: Matsuda, Kana, Ono, Shoko, Tanaka, Ikko, Inoue, Masaki, Kinowaki, Sayoko, Ishikawa, Marin, Tsuda, Momoko, Yamamoto, Keiko, Shimizu, Yuichi, Takahashi, Shuichiro, Hayase, Eiko, Hashimoto, Daigo, Teshima, Takanori, Sakamoto, Naoya
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Allografts
Atrophy
Bile
Duodenal Diseases - pathology
Duodenum - pathology
Endoscopy
Endoscopy, Gastrointestinal
Female
Graft versus host disease
Graft vs Host Disease - pathology
Hematology
Hematopoietic Stem Cell Transplantation
Humans
Ileal Diseases - pathology
Ileum - pathology
Intestinal Mucosa - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Article
Retrospective Studies
Stem cell transplantation
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Summary:Aim: To measure histological villous atrophy and to clarify the diagnostic accuracy of endoscopic villous atrophy in gastrointestinal graft-versus-host disease. Methods: Data for patients who underwent upper and/or lower endoscopic examinations after hematopoietic stem cell transplantation were retrospectively collected. In study 1, group A included 56 patients in whom GI-GVHD was histologically confirmed and group B included 60 patients in whom GI-GVHD was not histologically confirmed. Group C included 59 patients before HSCT. The lengths of villi and crypts in the duodenum and terminal ileum were histologically measured. In study 2, the diagnostic accuracies of villous atrophy of the duodenum and of the terminal ileum using magnifying endoscopy were evaluated. Results: In study 1, the lengths of villi and the villi/crypt (V/C) ratios of the duodenum and terminal ileum in group A were significantly smaller than those in the other groups ( p  
ISSN:0939-5555
1432-0584
DOI:10.1007/s00277-020-03966-y