Relationship between laryngopharyngeal reflux disease and gastroesophageal reflux disease based on synchronous esophageal and oropharyngeal Dx-pH monitoring

• Published in: American journal of otolaryngology 2020-05, Vol.41 (3), p.102441-102441, Article 102441
• Main Authors: Wang, Lei, Wang, Gang, Li, Lianyong, Fan, Xin, Liu, Hongdan, Sun, Zhezhe, Han, Haolun, Li, Baowei, Ding, Ruiying, Wu, Wei
• Format: Article
• Language: English
• Subjects: Acids; Comparative analysis; Data analysis; Edema; Electronic gastroscopy; Esophagitis; Esophagus; Exposure; Gastroesophageal reflux; Gastroscopy; Laryngopharyngeal reflux; Larynx; Monitoring; Oropharynx; Otolaryngology; Patients; pH effects; pH monitoring; Statistics; Telemedicine
• ISSN: 0196-0709; 1532-818X
• DOI: 10.1016/j.amjoto.2020.102441

To use the synchronous esophageal and oropharyngeal Dx-pH monitoring analysis to investigate the relationship between LPRD and GERD. Synchronous esophageal and oropharyngeal Dx-pH monitoring, electronic gastroscopy, reflux symptom index (RSI) and gastroesophageal reflux questionnaire (Gerd-Q) were collected from 514 consecutive patients and comparative analysis was done. A total of 85 patients had positive Ryan score and 251 cases had positive DeMeester or acid exposure time percent (AET) ≥4.2%. Moreover, 61.2% (52/85) of all LPRD cases were pure LPRD without GERD. There was no statistical difference in the acid exposure to oropharynx between pure LPRD group and LPRD+GERD group (U test, P > 0.05). Furthermore, there were no statistical differences in the other esophageal reflux data between pure GERD without LPRD group and LPRD+GERD group (U test, P > 0.05) apart from the number of episodes, which was higher in the pure GERD group than in LPRD+GERD group (U test, P = 0.027). Additionally, 149 patients were diagnosed with reflux esophagitis by electronic gastroscopy. No significant difference in the acid exposure to oropharynx was seen between different grades of reflux esophagitis (U test, P > 0.05). Among the LPRD patients, 32 cases (37.6%) were negative for Gerd-Q, Dx-pH esophageal probe and gastroscopy. The results of synchronous esophageal and oropharyngeal Dx-pH monitoring demonstrated that LPRD and GERD could co-exist as separate medical conditions. Our data suggest that some LPRD are not accompanied by GERD, and that LPRD is not secondary to severe GERD.