Methane suppressed dendritic cells activation in trinitrobenzene sulfonic acid induced colitis

•Our program is the first to show MS have a protective role in a murine model of TNBS-induced colitis.•MS significantly inhibited LPS-induced DCs maturation and OT-II CD4+ T cells activation.•MS alleviated intestinal inflammatory responses and inhibited DCs maturation in colitis.

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Bibliographic Details
Published in:International immunopharmacology 2020-05, Vol.82, p.106360-106360, Article 106360
Main Authors: Shao, Han, Zhang, Xu, Ruan, Linxing, Li, Jinbao, Chen, Feng, Guo, Long, Zhu, Jiali
Format: Article
Language:English
Subjects:
Cell activation
Colitis
Dendritic cells
Sulfonic acid
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Description
Summary:•Our program is the first to show MS have a protective role in a murine model of TNBS-induced colitis.•MS significantly inhibited LPS-induced DCs maturation and OT-II CD4+ T cells activation.•MS alleviated intestinal inflammatory responses and inhibited DCs maturation in colitis.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2020.106360