Thiol‐disulfide as a novel indicator of obstructive sleep apnea

Introduction Obstructive sleep apnea (OSA) is an oxidative stress disease, which has been considered to be a notable risk and associated with increased cardiovascular morbidity and mortality. Thiol‐disulfide homeostasis is as a novel indicator of oxidative stress. Objectives We aimed to evaluate thi...

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Published in:The clinical respiratory journal 2020-07, Vol.14 (7), p.652-658
Main Authors: Argüder, Emine, Parlak, Ebru Ş., Kılıç, Hatice, Hezer, Habibe, Neşelioğlu, Salim, Hasanoğlu, Hatice Canan, Yalçıner, Gökhan, Babademez, Mehmet Ali, Erel, Özcan
Format: Article
Language:English
Subjects:
Adult
antioxidants
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - mortality
Case-Control Studies
Disulfides - blood
Disulfides - metabolism
Female
Homeostasis
Homeostasis - physiology
Humans
Male
Middle Aged
obstructive sleep apnea (OSA)
Oxidative stress
Oxidative Stress - physiology
Patients
Prospective Studies
Risk Factors
Severity of Illness Index
Sleep apnea
Sleep Apnea, Obstructive - complications
Sleep Apnea, Obstructive - metabolism
Sleep Apnea, Obstructive - physiopathology
Sulfhydryl Compounds - blood
Sulfhydryl Compounds - metabolism
thiol/disulfide homeostasis
thiol‐disulfide
Turkey - epidemiology
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Summary:Introduction Obstructive sleep apnea (OSA) is an oxidative stress disease, which has been considered to be a notable risk and associated with increased cardiovascular morbidity and mortality. Thiol‐disulfide homeostasis is as a novel indicator of oxidative stress. Objectives We aimed to evaluate thiol‐disulfide homeostasis in a large patient population with OSA. Methods A total of 230 with OSA and 40 healthy controls were included in the study. Inclusion criteria for OSA patients are having apnoea‐hypopnoea index of ≥5/hour, being more than 18 years of age and having no previous treatment for OSA. Thiol‐disulfide analysis was done for the patients and control group. Blood thiol‐disulfide homeostasis was analysed using the new automatic method, developed by Erel and Neşelioğlu. Results Among all OSA subjects, 149 (64.8%) were males and the mean ages of the patients were 53.38 ± 10.22. Total thiol, native thiol (SH) and disulfide (SS) levels were significantly lower in OSA group compared to the control group (P 
ISSN:1752-6981
1752-699X
DOI:10.1111/crj.13180