The current markers of cancer stem cell in oral cancers

Head and neck cancer (HNC) constitute 5% of all reported cancers. Among all, the oral cavity cancer is the most frequent type of HNC which accounts for over half of HNC cases. Mouth cancer ranks the sixth leading cause of cancer-related mortality. Generally, conventional chemotherapy has shown succe...

Full description

Saved in:
Bibliographic Details
Published in:Life sciences (1973) 2020-05, Vol.249, p.117483-117483, Article 117483
Main Authors: Tahmasebi, Elahe, Alikhani, Milad, Yazdanian, Alireza, Yazdanian, Mohsen, Tebyanian, Hamid, Seifalian, Alexander
Format: Article
Language:English
Subjects:
Adenoid cystic carcinoma
Biomarkers, Tumor - metabolism
Cancer stem cells
Humans
Mouth Neoplasms - metabolism
Mouth Neoplasms - pathology
Mucoepidermoid carcinoma
Neoplastic Stem Cells - metabolism
Oral cavity
Oral squamous cell carcinoma
Salivary gland cancers
Stemness markers
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Head and neck cancer (HNC) constitute 5% of all reported cancers. Among all, the oral cavity cancer is the most frequent type of HNC which accounts for over half of HNC cases. Mouth cancer ranks the sixth leading cause of cancer-related mortality. Generally, conventional chemotherapy has shown success at decreasing relapse and metastasis rates and improves the overall prognosis. Recently, target therapy and targeted drug delivery systems have been introduced as promising treatments. The elimination of efficiency of current therapeutic strategies due to the spared cancer stem cells that cause chemotherapy resistance, relapse and metastasis. Inefficiency methodologies in the elimination of all cancer cells in the body are a major problem that remained to be resolved before to confront the new cancer therapies. Many studies imply to cancer stem cell markers as important agents for targeted anti-cancer as well as improving chemotherapy efficiencies. The potentials of targeted cancer therapy led us to search for novel markers in the mouth cancer stem cells especially in rare cancers. The aimed of this research was, first a comprehensive critical review of the previous studies on the markers of cancer stem cells in oral cancers including oral squamous cell carcinoma, salivary gland cancers, and to highlight the most common cancer stem cell markers which have potential to be exploited as indicators for the preneoplastic lesion malignancy, oral cancer progression, and/or treatment prognosis. [Display omitted]
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2020.117483