The effect of Saffron supplementation on waist circumference, HA1C, and glucose metabolism: A systematic review and meta-analysis of randomized clinical trials

•Saffron reduce waist Circumference.•Saffron reduce fasting blood sugar.•Saffron do not change HA1C. Carotenoids (including zeaxanthin and lycopene) and phytosterols reportedly confer beneficial effects on metabolic profile and function, which is of clinical importance. Thus, we sought to review the...

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Published in:Complementary therapies in medicine 2020-03, Vol.49, p.102298-102298, Article 102298
Main Authors: Rahmani, Jamal, Bazmi, Elham, Clark, Cain, Hashemi Nazari, Seyed Saeed
Format: Article
Language:English
Subjects:
Bias
Biomarkers
Cardiovascular disease
Carotenoids
Clinical trials
Coronary vessels
Crocin
Diabetes
Glucose
Glucose metabolism
HA1C
Hemoglobin
Hypertension
Insulin resistance
Intervention
Lycopene
Meta-analysis
Metabolic syndrome
Phytosterols
Randomization
Saffron
Search engines
Standard deviation
Subgroups
Supplements
Systematic review
Waist circumstance
Zeaxanthin
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Summary:•Saffron reduce waist Circumference.•Saffron reduce fasting blood sugar.•Saffron do not change HA1C. Carotenoids (including zeaxanthin and lycopene) and phytosterols reportedly confer beneficial effects on metabolic profile and function, which is of clinical importance. Thus, we sought to review the saffron effects on waist circumstance (WC), fasting plasma glucose (FPG), and HA1C concentrations reported in Randomized Control Trials (RCTs). A comprehensive systematic electronic search was performed in PubMed/MEDLINE, Embase, Google Scholar, Cochrane, Web of sciences, and SCOPUS to identify RCTs up to February 2019 without any language restrictions. The pooled weighted mean difference (WMD) calculated with DerSimonian-Laird random. PRISMA guidelines adhered to for this meta-analysis. Nine articles with 12 arms containing 595 participants were included in this study. Our study found WC was significantly reduced (WMD: −2.18 cm, 95 % CI: −4.05, −0.32) and FPG (WMD: −6.54 mg/dl, 95 % CI: −10.22, −2.85) following saffron intervention. Subgroup analysis highlighted that FPG levels (WMD: −10.24 mg/dl, 95 % CI: −15.76, −4.72) reduced significantly when intervention duration was longer than twelve weeks. There was no significant effect on HA1C levels (WMD: −0.13 mg/dl, 95 % CI: −0.31, 0.04) following saffron intervention. In conclusion, the present study indicates beneficial effects on WC and FPG, following saffron supplementation.
ISSN:0965-2299
1873-6963
DOI:10.1016/j.ctim.2020.102298