The influence of gene-chronic hepatitis C virus infection on hepatic fibrosis and steatosis

Host single nucleotide polymorphisms (SNPs) in different genes can play a role in chronic hepatitis C virus (HCV) infection and influence the presence of hepatic fibrosis and comorbidities such as hepatic steatosis. We assessed the combined effect of SNPs in the PNPLA3, MTTP, TM6SF2, and IFNL3/IFNL4...

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Published in:Diagnostic microbiology and infectious disease 2020-06, Vol.97 (2), p.115025-115025, Article 115025
Main Authors: Magri, Mariana Cavalheiro, Manchiero, Caroline, Prata, Thamiris Vaz Gago, Nunes, Arielle Karen da Silva, Oliveira Junior, José Santos de, Dantas, Bianca Peixoto, Tengan, Fátima Mitiko
Format: Article
Language:English
Subjects:
Adult
Aged
Brazil
Carrier Proteins - genetics
Fatty Liver - genetics
Fatty Liver - virology
Female
Genetic Association Studies
Genotype
Hepacivirus - genetics
Hepacivirus - pathogenicity
Hepatitis C
Hepatitis C, Chronic - genetics
Hepatitis C, Chronic - virology
Humans
Interferon lambda 3 and 4 (IFNL3/IFNL4)
Interferons - genetics
Lipase - genetics
Liver Cirrhosis - genetics
Liver Cirrhosis - virology
Male
Membrane Proteins - genetics
Microsomal triglyceride transfer protein (MTTP)
Middle Aged
Patatin-like phospholipase domain containing 3 (PNPLA3)
Polymorphism, Single Nucleotide
Single nucleotide polymorphisms (SNPs)
Transmembrane six superfamily member 2 (TM6SF2)
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Summary:Host single nucleotide polymorphisms (SNPs) in different genes can play a role in chronic hepatitis C virus (HCV) infection and influence the presence of hepatic fibrosis and comorbidities such as hepatic steatosis. We assessed the combined effect of SNPs in the PNPLA3, MTTP, TM6SF2, and IFNL3/IFNL4 genes in 288 Brazilian patients who were chronically infected with HCV. Hepatic fibrosis was observed in 246 (85.4%) patients and hepatic steatosis in 141 (49.0%) patients. PNPLA3 rs738409 (CG/GG) (P = 0.044) and TM6SF2 rs58542926 (CT) (P = 0.004) were alone associated with fibrosis, and PNPLA3 rs738409 (P 
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2020.115025