Increased Expression of LIPC Is Associated with Aggressive Phenotype of Borrmann Type 4 Gastric Cancer

Purpose To investigate lipase C hepatic type (LIPC) expression in Borrmann type 4 gastric cancer and its correlation with clinical outcome. The biological roles of LIPC in Borrmann type 4 gastric cancer progression were also investigated. Methods We determined LIPC expression in 324 primary gastric...

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Bibliographic Details
Published in:Journal of gastrointestinal surgery 2021-04, Vol.25 (4), p.900-910
Main Authors: Huang, Jin-yu, Zhang, Wei-lan, Xing, Ya-nan, Hou, Wen-bin, Yin, Song-cheng, Wang, Zhen-ning, Tan, Yu-en, Xu, Ying-ying, Zhu, Zhi, Xu, Hui-mian
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Cancer therapies
Cell cycle
Gastric cancer
Gastroenterology
Gene expression
Hospitals
Humans
Immunohistochemistry
Lymphatic Metastasis
Medical prognosis
Medical research
Medicine
Medicine & Public Health
Metabolism
Metastasis
Original Article
Patients
Phenotype
Prognosis
Proteins
Stains & staining
Stomach Neoplasms - genetics
Surgery
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Summary:Purpose To investigate lipase C hepatic type (LIPC) expression in Borrmann type 4 gastric cancer and its correlation with clinical outcome. The biological roles of LIPC in Borrmann type 4 gastric cancer progression were also investigated. Methods We determined LIPC expression in 324 primary gastric cancer tissues and 178 matched adjacent non-tumor tissues by immunohistochemistry. We explored the role of LIPC in Borrmann type 4 gastric cancer cell (OCUM-1) migration, invasion, proliferation, cell cycle, and expression of epithelial-mesenchymal transition-related genes by knocking down LIPC expression. Results LIPC expression was upregulated in Borrmann type 4 gastric cancer tissues compared with other types of gastric cancer and adjacent non-tumor tissues. High LIPC expression correlated with lymph node metastasis, advanced TNM stage, and poor overall survival in Borrmann type 4 gastric cancer patients. Multivariate analysis demonstrated that high LIPC expression was an independent prognostic factor in patients with Borrmann type 4 gastric cancer. By reducing LIPC expression, OCUM-1 cell invasion and migration were suppressed and Snail and MMP2 expression was downregulated, while E-cadherin expression was upregulated. Conclusions High LIPC expression correlates with poor clinical outcome and plays an important role in regulating cell migration and invasion in Borrmann type 4 gastric cancer.
ISSN:1091-255X
1873-4626
DOI:10.1007/s11605-020-04550-5