Insulin-Like Growth Factor-1 (IGF-1) and Reduced Tongue Pressure in Relation to Atherosclerosis Among Community-Dwelling Elderly Japanese Men: A Cross-Sectional Study

Even though higher serum insulin-like growth factor-1 (IGF-1) levels have a positive effect on preventing reduction in muscle strength, a U-shaped association between IGF-1 and mortality has been reported. Since a recent experimental study revealed that IGF-1 is associated with atherosclerotic lesio...

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Bibliographic Details
Published in:Dysphagia 2020-12, Vol.35 (6), p.948-954
Main Authors: Shimizu, Yuji, Yamanashi, Hirotomo, Noguchi, Yuko, Koyamatsu, Jun, Higashi, Miho, Fukui, Shoichi, Kawashiri, Shin-Ya, Arima, Kazuhiko, Takamura, Noboru, Maeda, Takahiro
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Arteriosclerosis
Atherosclerosis
Atherosclerosis - blood
Atherosclerosis - mortality
Cardiovascular diseases
Carotid Intima-Media Thickness
Cross-Sectional Studies
Ethylenediaminetetraacetic acid
Gastroenterology
Health aspects
Hepatology
Humans
Imaging
Independent Living
Inflammation
Insulin
Insulin-like growth factor I
Insulin-Like Growth Factor I - analysis
Insulin-like growth factors
Japan
Japan - epidemiology
Male
Medicine
Medicine & Public Health
Mens health
Mortality
Muscle strength
Older people
Original Article
Otorhinolaryngology
Palate
Population studies
Pressure
Radiology
Risk factors
Sarcopenia
Tongue
Tongue - physiology
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Summary:Even though higher serum insulin-like growth factor-1 (IGF-1) levels have a positive effect on preventing reduction in muscle strength, a U-shaped association between IGF-1 and mortality has been reported. Since a recent experimental study revealed that IGF-1 is associated with atherosclerotic lesion formation, the inflammatory status of atherosclerosis could act as a confounding factor on the association between IGF-1 levels and reduced muscle strength. This study aimed to clarify the atherosclerosis-specific association between IGF-1 levels and reduced muscle strength. We conducted a cross-sectional study of 410 elderly men aged 60–89 years. Since a reduction in maximum voluntary tongue pressure against the palate (MTP) is reportedly associated with sarcopenia, we evaluated muscle strength by using MTP and defined reduced MTP as the lowest tertiles of the study population. Among study population, 295 showed no atherosclerosis (carotid intima-media thickness 
ISSN:0179-051X
1432-0460
DOI:10.1007/s00455-020-10096-0