Comparison of midazolam and butorphanol combined with ketamine or dexmedetomidine for chemical restraint in howler monkeys (Alouatta guariba clamitans) for vasectomy

Background This study evaluated and compared cardiorespiratory and blood gas parameters, as well as sedation, analgesia and recovery of two protocols: ketamine (10 mg/kg) or dexmedetomidine (10 μg/kg), with midazolam (0.5 mg/kg) and butorphanol (0.3 mg/kg), IM (KBM and DBM, respectively) in brown ho...

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Published in:Journal of medical primatology 2020-08, Vol.49 (4), p.179-187
Main Authors: Fagundes, Natália, Castro, Marina Lopes, Silva, Renata Andrade, De Lima, Marcos Paulo Antunes, Braga, Carolina Silveira, Dos Santos, Eduardo Almeida Ruivo, Oliveira, Moira Ansolch, Mattoso, Claudio Roberto Scabelo, Pimenta, Eutálio Luiz Mariani, Beier, Suzane Lilian
Format: Article
Language:English
Subjects:
Alouatta guariba clamitans
anaesthesia
Analgesia
Anesthesia
blood gas
Butorphanol
dissociative drugs
interaction
Ketamine
Lactic acid
Latency
Midazolam
new world primate
non‐human primate
Pain perception
sedation
α2 agonists
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Summary:Background This study evaluated and compared cardiorespiratory and blood gas parameters, as well as sedation, analgesia and recovery of two protocols: ketamine (10 mg/kg) or dexmedetomidine (10 μg/kg), with midazolam (0.5 mg/kg) and butorphanol (0.3 mg/kg), IM (KBM and DBM, respectively) in brown howler monkeys (Alouatta guariba clamitans). Material and methods Twelve brown howler monkeys were selected in two groups and evaluated for cardiorespiratory parameters and sedation, from 5‐30 minutes after latency. Blood gas and arterial lactate were taken at 5 and 30 minutes. In the end, time and quality of recovery were evaluated. Results The HR in DBM group was significantly lower at all times. The sedation score was higher in DBM. Recovery in DBM was faster. All animals had moderate hypoxaemia. Conclusion Both protocols produce satisfactory anaesthesia and analgesia, but DBM provides deeper sedation with faster recovery. Oxygen supplementation is recommended in both due to hypoxaemia.
ISSN:0047-2565
1600-0684
DOI:10.1111/jmp.12467