Aluminum-Induced Toxicity in Salivary Glands of Mice After Long-term Exposure: Insights into the Redox State and Morphological Analyses

Several studies indicate aluminum (Al) as a potent toxicant, mainly related to central nervous system disorders. However, investigations about the Al effects over salivary glands are still scarce. In this way, the present study aimed to investigate whether the Al chloride (AlCl 3 ) is able of trigge...

Full description

Saved in:
Bibliographic Details
Published in:Biological trace element research 2020-12, Vol.198 (2), p.575-582
Main Authors: de Souza-Monteiro, Deiweson, de Oliveira Nunes, Paula Beatriz, de Oliveira Ferreira, Railson, Eiró, Luciana Guimarães, Bittencourt, Leonardo Oliveira, dos Santos Chemelo, Victoria, dos Santos, Sávio Monteiro, de Souza-Rodrigues, Renata Duarte, Monteiro, Marta Chagas, Lima, Rafael Rodrigues
Format: Article
Language:English
Subjects:
Aluminium
Aluminum
Aluminum chloride
Biochemistry
Biological stress
Biomedical and Life Sciences
Biotechnology
Body weight
Central nervous system
Distilled water
Ducts
Exocrine glands
Glands
Glutathione
Life Sciences
Malondialdehyde
Morphology
Nutrition
Oncology
Oxidative stress
Oxidoreductions
Parenchyma
Redox properties
Salivary gland
Salivary glands
Statistical analysis
Statistical methods
Stroma
Toxicants
Toxicity
Variance analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several studies indicate aluminum (Al) as a potent toxicant, mainly related to central nervous system disorders. However, investigations about the Al effects over salivary glands are still scarce. In this way, the present study aimed to investigate whether the Al chloride (AlCl 3 ) is able of triggering oxidative stress in parotid and submandibular glands of mice and also, if any morphological impairment is observed. For this, twenty mice were divided into two groups: Exposed group (EG), which received 18.5 mg/kg of AlCl 3 by intragastric gavage for 60 days and control group (CG), which received distilled water by intragastric gavage during the same period of time. After that, levels of reduced glutathione (GSH) and malonaldehyde (MDA) were analyzed and we performed morphological analyses by evaluating the area of parenchyma, stroma, acini, and ducts in both glands. Statistical analyses were performed by Student’s t test and two-way ANOVA, adopting p  
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-020-02091-1