Autonomic dysfunction is associated with neuropsychological impairment in Lewy body disease

Objective This study aimed to analyze the association of autonomic dysfunction with cognition, depression, apathy, and fatigue in Lewy body disease (LBD). Methods We included 61 patients [49 with idiopathic Parkinson’s disease, 7 with dementia with Lewy bodies, and 5 E46K-SNCA mutation carriers] and...

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Bibliographic Details
Published in:Journal of neurology 2020-07, Vol.267 (7), p.1941-1951
Main Authors: Del Pino, Rocío, Murueta-Goyena, Ane, Acera, Marian, Carmona-Abellan, Mar, Tijero, Beatriz, Lucas-Jiménez, Olaia, Ojeda, Natalia, Ibarretxe-Bilbao, Naroa, Peña, Javier, Gabilondo, Iñigo, Gómez-Esteban, Juan Carlos
Format: Article
Language:English
Subjects:
Aged
alpha-Synuclein - genetics
Apathy
Apathy - physiology
Autonomic nervous system
Autonomic Nervous System Diseases - diagnosis
Autonomic Nervous System Diseases - etiology
Autonomic Nervous System Diseases - physiopathology
Blood pressure
Blood Pressure - physiology
Cognition & reasoning
Cognitive ability
Cognitive Dysfunction - etiology
Cognitive Dysfunction - physiopathology
Conductance
Dementia disorders
Depression - etiology
Depression - physiopathology
Dysautonomia
Emotional behavior
Fatigue
Fatigue - etiology
Fatigue - physiopathology
Female
Health risk assessment
Heart diseases
Heart rate
Heart Rate - physiology
Humans
Hypotension
Lewy bodies
Lewy body disease
Lewy Body Disease - complications
Lewy Body Disease - physiopathology
Male
Medicine
Medicine & Public Health
Memory
Mental disorders
Middle Aged
Movement disorders
Neurodegenerative diseases
Neurology
Neuroradiology
Neurosciences
Original Communication
Parkinson Disease - physiopathology
Parkinson's disease
Respiration
Scopa
Skin tests
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Summary:Objective This study aimed to analyze the association of autonomic dysfunction with cognition, depression, apathy, and fatigue in Lewy body disease (LBD). Methods We included 61 patients [49 with idiopathic Parkinson’s disease, 7 with dementia with Lewy bodies, and 5 E46K-SNCA mutation carriers] and 22 healthy controls. All participants underwent a comprehensive battery of neuropsychological and clinical measures, autonomic symptom assessment with the SCOPA-AUT, analysis of non-invasive hemodynamic parameters during deep breathing, the Valsalva maneuver, and a 20-min tilt test, and electrochemical skin conductance measurement at rest (Sudoscan). Student’s t tests were used to assess group differences, and bivariate correlations and stepwise linear regressions to explore associations between autonomic function, cognition, depression, apathy, and fatigue. Results Compared to controls, patients who had significant impairment ( p  
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-020-09783-7