On age-dependent bone remodeling

A number of previous studies have investigated the possibilities of modelling the change in density of bones. Remodeling can be formulated at the constitutive or the kinematic level. In this work we introduce a formulation for the density growth process which takes not only the mechanical stimulus i...

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Bibliographic Details
Published in:Journal of biomechanics 2020-04, Vol.103, p.109701-109701, Article 109701
Main Authors: Papastavrou, Areti, Schmidt, Ina, Deng, Kefu, Steinmann, Paul
Format: Article
Language:English
Subjects:
Adaption
Age
Age Factors
Biomechanical Phenomena
Bone density
Bone Density - physiology
Bone remodeling
Bone Remodeling - physiology
Bones
Computer Simulation
Density
Density change
Finite element method
Growth
Humans
Models, Biological
Stress, Mechanical
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Summary:A number of previous studies have investigated the possibilities of modelling the change in density of bones. Remodeling can be formulated at the constitutive or the kinematic level. In this work we introduce a formulation for the density growth process which takes not only the mechanical stimulus into account but also the influence of age on the evolution of growth. We demonstrate the implementation in the context of the finite element method. This novel approach is illustrated for a simple uniaxial extension test and is verified against previous numerical results. Moreover, two further physiologically motivated examples are performed. The results of the proposed modified model show excellent agreement with comparable results from literature and are promising for the application to real-life problems.
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2020.109701