Gut microbiota and aging-A focus on centenarians

Gut microbiota (GM) is a dynamic organ throughout the lifespan. Aging is a complex process that comprises a plethora of mechanisms such as senescence, immunosenescence and inflammaging, representing important pathways of age-related diseases. GM structure could both influence and be influenced by ag...

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Published in:Biochimica et biophysica acta. Molecular basis of disease 2020-07, Vol.1866 (7), p.165765-165765, Article 165765
Main Authors: Cӑtoi, Adriana Florinela, Corina, Andreea, Katsiki, Niki, Vodnar, Dan Cristian, Andreicuț, Andra Diana, Stoian, Anca Pantea, Rizzo, Manfredi, Pérez-Martínez, Pablo
Format: Article
Language:English
Subjects:
Aged, 80 and over
Aging
Aging - genetics
Aging - metabolism
Centenarians
Gastrointestinal Microbiome - genetics
Gut microbiota
Humans
Longevity - genetics
Prebiotics
Probiotics
Probiotics - metabolism
Synbiotics
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Summary:Gut microbiota (GM) is a dynamic organ throughout the lifespan. Aging is a complex process that comprises a plethora of mechanisms such as senescence, immunosenescence and inflammaging, representing important pathways of age-related diseases. GM structure could both influence and be influenced by aging occurring changes within the host. A unique category of long living individuals exists, namely centenarians that have the outstanding capacity to adapt to various challenges. Longevity seems to be associated with certain GM which, among other factors, might render individuals more resistant to age-related diseases and subsequently to long living. Diet, prebiotics, probiotics and synbiotics may contribute to longevity through GM modulating. Currently, the exact mechanisms of the association between GM and the host in relation with extended lifespan remain unknown and should be further investigated. [Display omitted] •GM undergoes significant changes during aging. GM rearrangements could be a consequence or a cause of aging.•GM derangements during aging could be a result or a contributor to the age-related disorders.•Aging comprises mechanisms as senescence, immunosenescence and inflammaging, which are pathways of age-related diseases.•Centenarians are a category of long living individuals that have the outstanding capacity to adapt to various challenges.•Longevity seems to be associated with certain GM which might render individuals more resistant to age-related diseases.
ISSN:0925-4439
1879-260X
DOI:10.1016/j.bbadis.2020.165765