Acute liver failure associated with metabolic diseases: A 10‐year single‐center experience

Background Acute liver failure (ALF) is a rare multisystemic disease occurring in individuals with no history of liver disease, characterized by coagulopathy and / or hepatic encephalopathy secondary to acute liver injury. It is mostly caused by viral infections, drug intoxication, and metabolic dis...

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Bibliographic Details
Published in:Pediatrics international 2020-05, Vol.62 (5), p.609-614
Main Authors: Güven, Burcu, Sağ, Elif, Karagüzel, Gülay, Çakır, Murat
Format: Article
Language:English
Subjects:
acute liver failure
Adolescent
Alanine
Alanine transaminase
Alanine Transaminase - blood
Bilirubin
Bilirubin - blood
Child
Child, Preschool
Clinical outcomes
Consanguinity
Etiology
Family medical history
Female
Hepatic encephalopathy
Humans
Hypoglycemia
Hypoglycemia - epidemiology
Incidence
Infant
Intoxication
Liver diseases
Liver Diseases - epidemiology
Liver failure
Liver Failure, Acute - epidemiology
Liver Failure, Acute - etiology
Logistic Models
Male
metabolic disease
Metabolic Diseases - complications
Metabolic Diseases - epidemiology
Metabolic disorders
pediatric
Pediatrics
Retrospective Studies
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Summary:Background Acute liver failure (ALF) is a rare multisystemic disease occurring in individuals with no history of liver disease, characterized by coagulopathy and / or hepatic encephalopathy secondary to acute liver injury. It is mostly caused by viral infections, drug intoxication, and metabolic diseases (MD), and can also have an indeterminate etiology. In this study, we aimed to evaluate the demographic and clinical characteristics and clinical outcomes of the patients that presented to our clinic with MD‐associated ALF. Methods This retrospective study reviewed age, gender, parental consanguinity, family history, presence of encephalopathy, laboratory parameters, and clinical outcomes of the patients that presented to our clinic between January 2009 and January 2019. Patients with MD‐associated ALF were compared with patients in whom ALF was associated with other etiologies. Results The study included 39 patients (53.8% boys; mean age + SD 6.13 ± 1.43 years). The total and direct bilirubin, international normalized ratio, and ammoniac levels were significantly higher in patients with MD than in the others (P 
ISSN:1328-8067
1442-200X
DOI:10.1111/ped.14230