Study of HLA genes in Mexico Mayo/Yoremes Amerindians: Further support of gene exchange with Pacific Islanders

Mexican Mayo Amerindians live in southern Sonora and North Sinaloa states. They probably come from North or are related to First American Inhabitants established further North. A non-related sample of them have volunteered to HLA study in order to achieve a profile useful for their epidemiology and...

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Bibliographic Details
Published in:Human immunology 2020-05, Vol.81 (5), p.195-196
Main Authors: Arnaiz-Villena, Antonio, Juarez, Ignacio, Crespo-Yuste, Estefania, Lopez-Nares, Adrian, Callado, Alvaro, Vargas-Alarcon, Gilberto, Vaquero, Christian, Suarez-Trujillo, Fabio
Format: Article
Language:English
Subjects:
Alleles
Amerindians
Aymara
Aztecs
Blood Donors
Chimila
Gene Frequency
Haplotypes
Histocompatibility Testing
HLA
HLA Antigens - genetics
Humans
Indians, South American - genetics
Mapuche
Mayos
Mexicans
Mexico
Nahua
Pacific
Pacific Islands
Phylogeny
Quechua
Wiwa
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Summary:Mexican Mayo Amerindians live in southern Sonora and North Sinaloa states. They probably come from North or are related to First American Inhabitants established further North. A non-related sample of them have volunteered to HLA study in order to achieve a profile useful for their epidemiology and future transplant interstate programs, in addition to ascertain ancestry and anthropological studies. HLA typing was carried out by a standard methodology. HLA-B*48 allele(s) was found, which is characteristic of Pacific Amerindians and Pacific Islanders/southern Asians. Also, HLA-A*24 (most likely HLA-A*24:02) shows specific high frequencies in this population and also in indigenous people, like Aleuts, Alaska Yupik, Japan, Taiwan, Australia, New Zealand, Papua New Guinea, southern China and other Pacific Islands. Other Andean Amerindians also show a high HLA-A*24:02 frequencies. This confirms our previous results of a possible direct gene flow between Pacific Islanders/southern Asians and Amerindians. In addition, typical Amerindian haplotypes have been found in high frequency like HLA-A*24-B*39-DRB1*04:07-DQB1*03:02, HLA-A*02-B*35-DRB1*04:07-DQB1*03:02 and HLA-A*24-B*35-DRB1*04:07-DQB1*03:02, and new haplotypes are also described like HLA-A*02-B*35-DRB1*14:06-DQB1*03:01, HLA-A*02-B*48-DRB1*04:04-DQB1*03:02, and HLA-A*02-B*08-DRB1*04:07-DQB1*03:02. This study also supports that Americas peopling was not only carried out through Bering Strait but also through Pacific and Atlantic Oceans in an earlier time than proposed.
ISSN:0198-8859
1879-1166
1879-1166
DOI:10.1016/j.humimm.2020.02.012